Structure of PDB 8ugn Chain 5E Binding Site BS01

Receptor Information
>8ugn Chain 5E (length=214) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GALFVHRDTPENNPDTPFDFTPENYKRIEAIVKNYPEGHKAAAVLPVLDL
AQRQNGWLPISAMNKVAEILQVPPMRVYEVATFYTMYNRKPVGKYHIQVC
TTTPCMLRNSDSILEAIQKKLGIKVGETTPDKLFTLIEVECLGACVNAPM
VQINDNYYEDLTPKDIEEIIDELKAGKIPKPGPRSGRFSCEPAGGLTSLT
EPPKGPGFGVQAGL
Ligand information
Ligand IDFES
InChIInChI=1S/2Fe.2S
InChIKeyNIXDOXVAJZFRNF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04[Fe]1S[Fe]S1
CACTVS 3.341
OpenEye OEToolkits 1.5.0		S1[Fe]S[Fe]1
FormulaFe2 S2
NameFE2/S2 (INORGANIC) CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8ugn Chain 5E Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ugn High-resolution in situ structures of mammalian respiratory supercomplexes.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		C103 P107 C108 C144 L145 C148
Binding residue
(residue number reindexed from 1)		C100 P104 C105 C141 L142 C145
Annotation score1
Gene Ontology
Molecular Function
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0007399 nervous system development
GO:0048738 cardiac muscle tissue development
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0045271 respiratory chain complex I

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ugn, PDBe:8ugn, PDBj:8ugn
PDBsum8ugn
PubMed38811722
UniProtA0A4X1VRV3

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