Structure of PDB 6qnr Chain 58 Binding Site BS01

Receptor Information

>6qnr Chain 58 (length=138) Species: 300852 (Thermus thermophilus HB8)

MKTYVPKQVEPRWVLIDAEGKTLGRLATKIATLLRGKHRPDWTPNVAMGD
FVVVVNADKIRVTGKKLEQKIYTRYSGYPGGLKKIPLEKMLATHPERVLE
HAVKGMLPKGPLGRRLFKRLKVYAGPDHPHQAQRPEKL

Ligand information

>6qnr Chain 1H (length=2890)

ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaug
aaggacguggcuaccugcgauaagccagggggagccgguagcgggcgugg
aucccuggauguccgaaugggggaacccggccggcgggaacgccggucac
cgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguaccc
agaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggg
gaccagccuaaaccguccggcuuguccgggcggggucguggggcccucgg
accgaauccccagccuagccgaagcuguugggaagcagcgccagagaggg
ugaaagccccguaggcgaaagguggggggauaggugaggguacccgagua
ccccgugguucguggagccaugggggaaucugggcggaccaccgccuaag
gcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggu
gaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuua
caagcagucacggccccgcaagggguuguggcgugccuauugaagcauga
gccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcgu
agggaaaccgaguccgaacagggcgcaaacggccgaaaaguccgcggccg
uggacccgaaaccgggcgagcuagcccuggccagggugaagcugggguga
gacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagc
uggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccc
cgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagca
cugauagggcuagggggcccaccagccuaccaaacccugucaaacuccga
agggucccagguggagccugggagugagggcgcgagcgauaacguccgcg
uccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucuggg
cuaagugguaaaggauguggcgccgcgaagacagccaggauguuggagca
gccaucauuuaaagagugcguuagcucacuggucgaguggcgccgcgccg
aaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaug
accccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcg
agggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaa
agagggugagaaucccucucgccguaagcccaaggguuccuacgcaaugg
ucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagc
cgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggg
gacgcucuaggcuagggggaccggagccauggacgagcccggccagaagc
gcagggugggagguaggcaaauccgccucccaacaagcucugcguggugg
ggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagc
cucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggc
gggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucug
caaguuggccccguaacuucgggagaaggggugcucccuggggugaugag
ccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacac
agcucucugcgaacucguaagaggagguauagggagcgacgcuugcccgg
ugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggug
aacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucgg
guaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggc
gagggacccggugaaauugaacuggccgugaagaugcggccuacccgugg
caggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuu
ggucgcgccugcguaggauaggugggagccugugaacccccgccuccggg
ugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaa
cccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucg
ccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacgga
aauccgccggagagcgcaaggguagaagggggccugacugcgaggccugc
aagccgagcaggggcgaaagccgggccuagugaaccgguggucccgugug
gaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcuga
ucucccccgagcguccacagcggcggggagguuuggcaccucgaugucgg
cucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcc
cauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggu
cucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacg
agaggaccggaagggacgcaccucugguuucccagcugucccuccagggg
cauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaa
gcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaag
gacccgggaagaccacccgguggaugggccggggguguaagcgccgcgag
gcguugagccgaccggucccaaucguccgaggucuugacc

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..<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>....
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<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>
>>.>.........<<....>>...<<<<<.....<<.....>>....>>>
>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..
<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<
.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....
<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)
))......]].>>>>>>.]]...............<<....>>....]].
........<<<<....>>>>..................>>>>>>>>>>>.
......<<<<<<<<<<<....>>>>>>>>>>>...<............>.
<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>..
.<<....>>..<<<<.....>>>>.....<<..>>....>>>>>>>>>>>
>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<....
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<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<..
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.>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>
>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<
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.........)))......>>>>>>.>>>...>>>>>>><<<<<<<<....
.>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<...
.>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....
<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.
....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>
>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<.
...<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<
<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>
<...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>
>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>
.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<........
.<.....<<<<<...............>>>>><<<<<<<<<<<<.....>
>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>.
.<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<
<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>.
.>>>>><<<<<<.......>>>>>>........<...........<<<<<
<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>
>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<
<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<
<<<<<<<<<...........<<.<<..<<<.......<<<<<<<....>>
>>>>>....>>>............>>.>>..>>>>>>>>>>>>>>>>...
<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><
<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.....
..>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<....
..>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>
>..)))>>>>>>.............>>>>..]]>>>>.......<<<<..
.<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<
<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>
>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>...
.....)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.......
........>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>
>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>
>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<
<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>
>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6qnr Importance of potassium ions for ribosome structure and function revealed by long-wavelength X-ray diffraction.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): K2 T3 W13 T22 L23 G24 R25 T28 R35 K37 N45 F51 T63 K65 K66 Q69 K70 Y72 R74 Y75 S76 Y78 L82 K83 R97 E100 H101 A102 G105 M106 P108 G110 P111 L112 R114 K118 Q131
• Binding residue (residue number reindexed from 1): K2 T3 W13 T22 L23 G24 R25 T28 R35 K37 N45 F51 T63 K65 K66 Q69 K70 Y72 R74 Y75 S76 Y78 L82 K83 R97 E100 H101 A102 G105 M106 P108 G110 P111 L112 R114 K118 Q131

Gene Ontology

Molecular Function

• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation
• GO:0017148 negative regulation of translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6qnr, PDBe:6qnr, PDBj:6qnr
• PDBsum: 6qnr
• PubMed: 31175275
• UniProt: P60488|RL13_THET8 Large ribosomal subunit protein uL13 (Gene Name=rplM)