Structure of PDB 8qu1 Chain 5 Binding Site BS01

Receptor Information
>8qu1 Chain 5 (length=371) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRVYEIPGLEPITFAGKMHFVPWLARPIFPPWDRGYKDPRFYRSPPLHEH
PLYKDQACYIFHHRCRLLEGVKQALWLTKTKLIEGLPEKVLSLVDDPRNH
IENQDECVLNVISHARLWQTTEEIPKRETYCPVIVDNLIQLCKSQILKHP
SLARRICVQNSTFSATWNRESLLLQVRGSGGARLSTKDPLPTIASREEIE
ATKNHVLETFYPISPIIDLHECNIYDVKNDTGFQEGYPYPYPHTLYLLDK
ANLRPHRLQPDQLRAKMILFAFGSALAQARLLYGNDAKVLEQPVVVQSVG
TDGRVFHFLVFQLNTTDLDCNEGVKNLAWVDSDQLLYQHFWCLPVIVEPV
GPVGFKPETFRKFLALYLHGA
Ligand information
>8qu1 Chain A (length=938) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccaauaaaguauagg
cgauagaaauugggcgcaauagauauaguaccgcaagggaaagaugaaaa
auaccaagcauaauauagcaaggacuaaccccuauaccuucugaugaauu
aacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaacca
gacgaagccuggugauagcugguuguccaagauagacaacuuuaaauuug
cccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaa
cagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuua
acacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagc
ucaacacucccaaacauauaacugaacuccucacacccaauuggaccaau
cuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauu
cuccuccgcauaagccugcgucagaucacugacaauuaacagcccaauau
cuacaaucaaccaacaagucauuauuacccucacugucaacccaaggcau
gcucauaaggaaagguuaaaaaaaguaaaaggaaacaucaccucuagcau
caccaguauuagaggccagcugucucuuacuuuuaaccagugaaauugac
cugcccgugaggcgggcauaacacagcaagacgagacccuauggagcuuu
aauuuauuaaugcaaacaccugcauuaaaaauacaugcuaagacuucacc
agucaaagcgaacaguuacccuaggguaucuacuuuauuccucccuguac
gaaaggacaagagaaauaaggccuacuucacaaagcgccuucuaaaugau
aucaucucaacuuaauacccacacccaagaacaggguu
<<<.......<<<<................................<<..
...>>.......>>.>>.............<<....>>............
......>>>...........<<<.......>>>...<.<....>.>.<<<
<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<
<.<...>.>>>>...>..>.>>..<<<<<<....<.><<<.<<<<<<<<<
<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<...
...>>>>>>>>>>...<<<......>>>....<<<.<<<...<.......
.......<....<<<.........>>>....>.......<<<......>>
>.....................>...>>>>>>........>>>>>>...<
<<<<......>>>>>.........>>>>>><......<<..<<<....>>
><<<<..<<<<........<<<<<....>>>>>......<<<...<<<<.
......................>>>>.......>>>.....<<..>>.>>
>>.....>>>>..<<<<...<<<<<<<<.<<.........<<<<<<....
.........>>>>>>........>>.>>>>>>>>>>>>.>>.....>...
..<<<<<.....>>>>>.......<<..<<<.....<<<<<.<<<<<<..
..<<..<<<<<<<<......>>>>>>>.>>>.....<<<..<<<<.....
>>>>..>>>....>>>>..>>>>>>>..>>>.>>..<<<.<<<.......
..........>>>.>>><<<<<...<<<....>>>.>>>>>.<<<.<...
.........>.>>>........<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8qu1 GTPBP8 plays a role in mitoribosome formation in human mitochondria.
Resolution2.74 Å
Binding residue
(original residue number in PDB)		R80 P85 F87 Y88 R89 S90 L93 H96 I106 H108 H109 R110 R112 R173 H266 I270 L299 R300 H302 R350 Q384 H385 W387
Binding residue
(residue number reindexed from 1)		R34 P39 F41 Y42 R43 S44 L47 H50 I60 H62 H63 R64 R66 R127 H220 I224 L253 R254 H256 R304 Q338 H339 W341
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005761 mitochondrial ribosome
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8qu1, PDBe:8qu1, PDBj:8qu1
PDBsum8qu1
PubMed38969660
UniProtQ9BZE1|RM37_HUMAN Large ribosomal subunit protein mL37 (Gene Name=MRPL37)

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