Structure of PDB 8qsj Chain 5 Binding Site BS01

Receptor Information

>8qsj Chain 5 (length=394) Species: 9606 (Homo sapiens)

AYEWGVRSTRKSEPPPLDRVYEIPGLEPITFAGKMHFVPWLARPIFPPWD
RGYKDPRFYRSPPLHEHPLYKDQACYIFHHRCRLLEGVKQALWLTKTKLI
EGLPEKVLSLVDDPRNHIENQDECVLNVISHARLWQTTEEIPKRETYCPV
IVDNLIQLCKSQILKHPSLARRICVQNSTFSATWNRESLLLQVRGSGGAR
LSTKDPLPTIASREEIEATKNHVLETFYPISPIIDLHECNIYDVKNDTGF
QEGYPYPYPHTLYLLDKANLRPHRLQPDQLRAKMILFAFGSALAQARLLY
GNDAKVLEQPVVVQSVGTDGRVFHFLVFQLNTTDLDCNEGVKNLAWVDSD
QLLYQHFWCLPVIKKRVVVEPVGPVGFKPETFRKFLALYLHGAA

Ligand information

>8qsj Chain A (length=1418)

gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauaccaagcauaauau
agcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaa
cuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccu
aagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaaga
uuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguc
caagauagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaa
uccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggaca
cuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguagg
ccuaaaagcagccaccaauuaagaaagcguucaagcucaacacaaaaaau
cccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacc
cuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccg
cauaagccugcgucagacacugaacugacaauuaacagcccaauaucuac
aaucaaccaacaagucauuauuacccucacugucaacccaacacaggcau
gcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuacc
ccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggca
ccgccgcuccacgaggguucagcugucucuuacuuuuaaccagugaaauu
gaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccua
uggagcuuuaauuuauuaaugcaaacaaccugcauuaaaaauuucgguug
gggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuu
caccagucaaagcgaacacucaauugauccaauaacuugaccaacggaac
aaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaac
aauagggcgaccucgauggaucaggacaucccgauggugcagccgcuauu
aaagguucguuuaacgauuaaaguccuacgugaucugaguucagaccgga
guaauccaggucgguuucuaucuacuuaaauuccucccuguacgaaagga
caagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauuc
ucaacuuaguauacccaccccacccaagaacaggguuuauauauauauau
auauauauauauauauau

<<<.......<<<<....................................
.<<....>>.........<.....<<.....>>....>........>>.>
>.............<<....>>..................>>>.......
....<<<.......>>>...<.<........>.>.<<<<<<.........
<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<
<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....
>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<
<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<..........
>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.
..<<<......>>>....<<<.<<<...<..............<....<<
<.........>>>....>.......<<<......>>>.............
..............>...>>>>>>........>>>>>>...<<<<<....
..>>>>>.........>>>>>><......<<..<<<....>>><<<<..<
<<<........<<<<<........>>>>>......<<<...<<<<.....
..................>>>>.......>>>.....<<......>>.>>
>>.....>>>>..<<<<...<<<<<<<<.<<................<<<
<<<..<<<.........>>>...<<<<<<.............>>>>>>..
..<<.>>....>>.>>>>........>>.>>>>>>>>>>>>.>>.....>
.....<<<<<........>>>>>.......<<..<<<.<<<.....<<<<
.<<<<<<..<<<<<.<<<<<<<<.......>>>>>>>>>>>>>..<<<<.
....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.
....>>>>..>>>.....>>.........<<<....>>>...........
.>>>>..>>>>>>.......<<<...<<<<<<<...<<.......>>...
>>>>>>>>>.>.....<<<<.<<<<<<..<<.<<<<<<......>>>>>>
...>>.<<<<<.>>>>>.....>>>>>..>...>>>>......<<<<<<<
....>>>.>>>>...>>>..>>>.>>...<<<.<<<..............
...>>>.>>><<<<<...<<<....>>>.>>>>>......<<<.......
.....>>>.............<<<<.......>>>>.<<<<<<..>>>>>
>.<<<<<<<..>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8qsj Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): Y31 E32 W33 G34 V35 R36 S37 F66 P68 W78 R80 P85 F87 Y88 R89 S90 L93 H96 H109 R110 R112 I170 R173 R223 H266 I270 R300 P301 H302 Q305 R350 Q384 H385 W387 C388 L389 R395
• Binding residue (residue number reindexed from 1): Y2 E3 W4 G5 V6 R7 S8 F37 P39 W49 R51 P56 F58 Y59 R60 S61 L64 H67 H80 R81 R83 I141 R144 R194 H237 I241 R271 P272 H273 Q276 R321 Q355 H356 W358 C359 L360 R366

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005761 mitochondrial ribosome
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8qsj, PDBe:8qsj, PDBj:8qsj
• PDBsum: 8qsj
• PubMed: 38042949
• UniProt: Q9BZE1|RM37_HUMAN Large ribosomal subunit protein mL37 (Gene Name=MRPL37)