Structure of PDB 8kg9 Chain 5 Binding Site BS01

Receptor Information
>8kg9 Chain 5 (length=676) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYSLTVNMEHLI
GYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRALNSLPTFQLILN
SNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTT
SITINNFNSNTVSLPRSCLSNCGPDPYIIIHESSKFIDQQFLKLQEIPEL
VPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKGVAIRTPYIK
ILGIQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIF
GNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFV
EKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCI
DEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGR
YDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGN
ANAMQNQQEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTI
RKQLLINELESTERSSIPITIRQLEAIIRITESLAKLELSPIAQERHVDE
AIRLFQASTMDAASQDPTSLSEIRRFEQELKRRLPIGWSTSYQTLRREFV
DTHRFSQLALDKALYALEKHEYRSGV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8kg9 Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Resolution4.52 Å
Binding residue
(original residue number in PDB)		A447 V453 F462 A507
Binding residue
(residue number reindexed from 1)		A368 V374 F383 A428
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006279 premeiotic DNA replication
GO:0006368 transcription elongation by RNA polymerase II
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0031507 heterochromatin formation
GO:0031509 subtelomeric heterochromatin formation
GO:0032508 DNA duplex unwinding
GO:0033260 nuclear DNA replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8kg9, PDBe:8kg9, PDBj:8kg9
PDBsum8kg9
PubMed37730685
UniProtP29496|MCM5_YEAST Minichromosome maintenance protein 5 (Gene Name=MCM5)

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