Structure of PDB 8b9d Chain 5 Binding Site BS01

Receptor Information
>8b9d Chain 5 (length=597) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWI
EVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEV
LQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISI
QCRSCRNTLTNIAMRPGLEGYALPRKCCPLDPYFIMPDKCKCVDFQTLKL
QELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKGVGIRSS
YIRVLGIQVDTGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMK
KAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPI
GVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKM
REDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKG
EDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTEID
LAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSS
IPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAA
Ligand information
Receptor-Ligand Complex Structure
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PDB8b9d How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		V418 F427 K471 A472
Binding residue
(residue number reindexed from 1)		V368 F377 K421 A422
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0042555 MCM complex
GO:0043231 intracellular membrane-bounded organelle
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b9d, PDBe:8b9d, PDBj:8b9d
PDBsum8b9d
PubMed37506699
UniProtP33992|MCM5_HUMAN DNA replication licensing factor MCM5 (Gene Name=MCM5)

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