Structure of PDB 7plo Chain 5 Binding Site BS01

Receptor Information
>7plo Chain 5 (length=614) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWI
EVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEV
LQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISI
QCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCK
CVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYS
IKKFVGVGIRSSYIRVLGIQVDTGAVSPQEEEEFRRLAALPNVYEVISKS
IAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKS
QLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLAD
GGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAA
NSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVIT
LHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYII
MRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVE
EALRLFQVSTLDAA
Ligand information
Receptor-Ligand Complex Structure
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PDB7plo A conserved mechanism for regulating replisome disassembly in eukaryotes.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		S410 S417 V418 R420 F427 K471 A472
Binding residue
(residue number reindexed from 1)		S372 S379 V380 R382 F389 K433 A434
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0042555 MCM complex
GO:0043231 intracellular membrane-bounded organelle
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7plo, PDBe:7plo, PDBj:7plo
PDBsum7plo
PubMed34700328
UniProtP33992|MCM5_HUMAN DNA replication licensing factor MCM5 (Gene Name=MCM5)

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