Structure of PDB 7oie Chain 5 Binding Site BS01

Receptor Information
>7oie Chain 5 (length=387) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YEWGVRSTRKSEPPPLDRVYEIPGLEPITFAGKMHFVPWLARPIFPPWDR
GYKDPRFYRSPPLHEHPLYKDQACYIFHHRCRLLEGVKQALWLTKTKLIE
GLPEKVLSLVDDPRNHIENQDECVLNVISHARLWQTTEEIPKRETYCPVI
VDNLIQLCKSQILKHPSLARRICVQNSTFSATWNRESLLLQVRGSGGARL
STKDPLPTIASREEIEATKNHVLETFYPISPIIDLHECNIYDVKNDTGFQ
EGYPYPYPHTLYLLDKANLRPHRLQPDQLRAKMILFAFGSALAQARLLYG
NDAKVLEQPVVVQSVGTDGRVFHFLVFQLNTTDLDCNEGVKNLAWVDSDQ
LLYQHFWCLPVIVEPVGPVGFKPETFRKFLALYLHGA
Ligand information
>7oie Chain A (length=1472) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccagcaaccuuagcc
aaaccauuuacaaauaaaguauaggcgauagaaauugauggcgcaauaga
uauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagc
aaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuu
ugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaag
aacagcuaagagcacacccgucuauguagcaaaauagugggaagauuuau
agguagaggcgacaaaccuaccgagccuggugauagcugguuguccaaga
uagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuugu
aaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaa
aaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagc
agccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacau
auaacugaacuccucacacccaauuggaccaaucuaucacccuauagaag
aacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccu
gcgucagauacugacaauuaacagcccaauaucuacaaucaaccaacaag
ucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaag
guuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuacca
aaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagug
acacauguuuaacggccgcgguuaaccgugcaaagguagcauaaucacuu
guuccuuaaauagggaccuguaugaauggcuccacgaggguucagcuguc
ucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaa
cacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaaca
guaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaa
ccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauu
gauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgca
auccuauucuagaguccauaucaacaauaggguuuacgaccucgauguug
gaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaa
cgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgg
uuucuaucuacuuuauuccucccuguacgaaaggacaagagaaauaaggc
cuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagau
acccacacccaagaacaggguu
<<<.......<<<<....................................
<......>.............<<.....>>.........>>.>>......
.......<<....>>......................>>>..........
.<<<.......>>>...<............>.<<<<<<.........<<<
.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<
<<..<<<...>>>...<<<..<<<<........>>>>.>>>....>>>.>
>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<..
..<<<<....>>>>.<<.<<<<<<<<<<.....<<......>>.....>>
>>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>...<<<....
..>>>....<<<.<<<...<..............<....<<<........
.>>>....>.......<<<......>>>......................
.....>...>>>>>>........>>>>>>...<<<<<......>>>>>..
.......>>>>>><......<<..<<<....>>><<<<..<<<<......
..<<<<<...>>>>>......<<<...<<<<...................
....>>>>.......>>>.....<<......>>.>>>>.....>>>>..<
<<<...<<<<<<<<.<<.........<......<<<<<<..<<<......
...>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<
<<....>>>..>>>>><<<<<....>>>>>........<...........
<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>
>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>....
...<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<....
......>>>>>>>>.>>>>..<<<<.....>>>><<<<<<..........
.>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.....
....<<<....>>>............>>>>..>>>>>>.......<<<..
<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.........<
<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>
>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>..
..>>..>>>.>>..<<<.<<<.................>>>.>>><<<<<
...<<<....>>>.>>>>>......<<<................>>>...
......<<<<.......>>>>.
Receptor-Ligand Complex Structure
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PDB7oie A distinct assembly pathway of the human 39S late pre-mitoribosome.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		Y31 E32 W33 G34 V35 R36 S37 F66 P68 R80 P85 R86 F87 Y88 S90 L93 H96 L98 H108 H109 R110 R112 R223 D264 H266 C268 I270 R300 P301 H302 Q305 Q384 H385 W387 C388
Binding residue
(residue number reindexed from 1)		Y1 E2 W3 G4 V5 R6 S7 F36 P38 R50 P55 R56 F57 Y58 S60 L63 H66 L68 H78 H79 R80 R82 R193 D234 H236 C238 I240 R270 P271 H272 Q275 Q354 H355 W357 C358
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005761 mitochondrial ribosome
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7oie, PDBe:7oie, PDBj:7oie
PDBsum7oie
PubMed34315873
UniProtQ9BZE1|RM37_HUMAN Large ribosomal subunit protein mL37 (Gene Name=MRPL37)

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