Structure of PDB 7ase Chain 5 Binding Site BS01

Receptor Information
>7ase Chain 5 (length=421) Species: 5693 (Trypanosoma cruzi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QATVNIGTIGHVAHGKSTVVKALSGVKTQKYHREAVMNITIHLGYANAKV
FKCDKCELPAAFHAFPSSQPDKTDCPTCGSPLTLKRHFSFVDCPGHDVLM
ATMLNGAAIMDAALLLIAANEPFPQPQTLEHLKAVEIMRLANLVILQNKI
DLVGEVHAQDQYHKIRNYIDSTIGSNIPIIPISAQLKRNIDYLLEYLCHI
PLPTRQLNCPAHMTVVRSFDINKPGEVDIENLRGGVAGGTVTRGIIRVNQ
VLEIRPGQVHAQTGGTFSCTPLRTRALTLKAEDNSLQYAVPGGLIAVGTT
LDPTLTRQDKMVGHMIADEGSLPEVYAEIEVQYFLFEEMVGRSKQRDRNA
KRVQKLNLQETLQINVGTLTAGATVVNITKNPDIAKLTLVTPVCCTLDEH
IAISRLVEKNFRLIGWGIIRR
Ligand information
>7ase Chain 1 (length=75) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcaccguggcgcaguggaagcgcgaugggcucauaacccauaggacguu
ggaucgaaaccaaccggugcuacca
<<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<
<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB7ase Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts.
Resolution3.33 Å
Binding residue
(original residue number in PDB)		Q78 K79 Y80 F268 D269 K272 R282 V285 K329 A345 Q357
Binding residue
(residue number reindexed from 1)		Q29 K30 Y31 F219 D220 K223 R233 V236 K280 A296 Q308
Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016787 hydrolase activity
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
Cellular Component
GO:0005829 cytosol
GO:0005850 eukaryotic translation initiation factor 2 complex

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Biological Process
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Cellular Component
External links
PDB RCSB:7ase, PDBe:7ase, PDBj:7ase
PDBsum7ase
PubMed33357443
UniProtQ4CPV7

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