Structure of PDB 6vmi Chain 5 Binding Site BS01

Receptor Information
>6vmi Chain 5 (length=394) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AYEWGVRSTRKSEPPPLDRVYEIPGLEPITFAGKMHFVPWLARPIFPPWD
RGYKDPRFYRSPPLHEHPLYKDQACYIFHHRCRLLEGVKQALWLTKTKLI
EGLPEKVLSLVDDPRNHIENQDECVLNVISHARLWQTTEEIPKRETYCPV
IVDNLIQLCKSQILKHPSLARRICVQNSTFSATWNRESLLLQVRGSGGAR
LSTKDPLPTIASREEIEATKNHVLETFYPISPIIDLHECNIYDVKNDTGF
QEGYPYPYPHTLYLLDKANLRPHRLQPDQLRAKMILFAFGSALAQARLLY
GNDAKVLEQPVVVQSVGTDGRVFHFLVFQLNTTDLDCNEGVKNLAWVDSD
QLLYQHFWCLPVIKKRVVVEPVGPVGFKPETFRKFLALYLHGAA
Ligand information
>6vmi Chain A (length=1527) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcaua
auauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaa
auaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcu
accuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggg
aagauuuauagguagaggcgacaaaccuaccgagccuggugauagcuggu
uguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccuc
uaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuug
gacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauag
uaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccca
cuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauugga
ccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaa
acauucuccuccgcauaagccugcgucagauuaaaacacugaacugacaa
uuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacu
gucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaag
gaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagc
aucaccaguauuagaggcaccgccugcccagugacacauguuuaacggcc
gcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauag
ggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaac
cagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacga
gaagacccuauggagcuuuaauuuauuaaugcaaacaguauaccaaaccu
gcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccga
gcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaa
uaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuau
ucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucagg
acaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaa
aguccuacgugaucugaguucagaccggaguaauccaggucgguuucuau
cuacuuucaaauuccucccuguacgaaaggacaagagaaauaaggccuac
uucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauuau
acccacacccacccaagaacaggguuu
<<<.......<<<<....................................
.<......>.........<.....<<.....>>....>........>>.>
>.............<<....>>......................>>>...
........<<<.......>>>...<.<........>.>.<<<<<<.....
....<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....
<<<<<.<<<..<<.......>>...<<<..<<<<........>>>>.>>>
....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>.
.<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......
....>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>
>>>...<<<......>>>....<<<.<<<...<..............<..
...<<.........>>.....>.......<<<......>>>.........
...........................>...>>>>>>........>>>>>
>...<<<<<......>>>>>.........>>>>>><......<<..<<<.
...>>><<<<..<<<<........<<<<<..............>>>>>..
....<<<...<<<<.......................>>>>.......>>
>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<
................<<<<<<..<<<.........>>>...<<<<<<..
...........>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><
<<<<<......>>>>>>........<...........<<<<<<.....>>
>>>>.....>....>>>....>>.>>>>........>>.>>>>>>>>>>>
>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<
......<<<<.<<<<<<..<<<<..<<<<<<<<.....<..>.......>
>>>>>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>
..<......<<<..<<<<.....>>>>..>>>.....>.........<<<
....>>>............>>>>..>>>>>>.......<<<...<<<<<<
<...<<.......>>...>>>>>>>....>>.>.......<.<<<.<<<<
<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>....
.>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>
>>.>>...<.<<<.<<<.................>>>.>>><<<<<...<
<<....>>>.>>>>>......<<<................>>>......>
..........<<<<.......>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6vmi Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation.
Resolution2.96 Å
Binding residue
(original residue number in PDB)		Y31 E32 W33 G34 V35 S37 K40 R72 P85 R86 F87 Y88 R89 S90 L93 R110 R173 R223 H266 I270 L299 R300 P301 H302 R303 Q305 R350 Q384 H385 W387 C388 L389
Binding residue
(residue number reindexed from 1)		Y2 E3 W4 G5 V6 S8 K11 R43 P56 R57 F58 Y59 R60 S61 L64 R81 R144 R194 H237 I241 L270 R271 P272 H273 R274 Q276 R321 Q355 H356 W358 C359 L360
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005761 mitochondrial ribosome
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6vmi, PDBe:6vmi, PDBj:6vmi
PDBsum6vmi
PubMed32737313
UniProtQ9BZE1|RM37_HUMAN Large ribosomal subunit protein mL37 (Gene Name=MRPL37)

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