Structure of PDB 6raw Chain 5 Binding Site BS01

Receptor Information
>6raw Chain 5 (length=576) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INLQAVKKKYKEFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIEMEDLVG
FDETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLS
SNANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSYALPRKCNPK
CPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCER
VVPGNRVLIQGIYSIRKGVRAPYMRVVGITVDSEGAGAISRYSNITSDEE
EHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGL
CRRGDINVLLLGDPGTAKSQLLKFVEKVPIAVYTSGKGGLTASVMKDPQT
RNFVMEGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGIT
TTLNSRCSVLAAANSIFGRWDDTKGEENIDFMPTILSRFDMIFIVKDIHD
ESRDITLAKHIINVHLSSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPR
LSEAAGEKLKSRYVLMRSGAGQQEKASDKRITVRQLEAVIRISESLAKIR
LQPFATDEHVNEALRLFQVSTLDAAM
Ligand information
Receptor-Ligand Complex Structure
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PDB6raw Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		R190 L204 T412 V415 R422 F424 K468
Binding residue
(residue number reindexed from 1)		R145 L153 T341 V344 R351 F353 K396
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000712 resolution of meiotic recombination intermediates
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006279 premeiotic DNA replication
GO:0030261 chromosome condensation
GO:0032508 DNA duplex unwinding
GO:0042023 DNA endoreduplication
GO:0051321 meiotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex
GO:0042555 MCM complex
GO:0043231 intracellular membrane-bounded organelle
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6raw, PDBe:6raw, PDBj:6raw
PDBsum6raw
PubMed31484077
UniProtQ9VGW6|MCM5_DROME DNA replication licensing factor Mcm5 (Gene Name=Mcm5)

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