Structure of PDB 8h6j Chain 4G Binding Site BS01

Receptor Information
>8h6j Chain 4G (length=784) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPGLGRGATGFYEKDDEEADAIYAALDKRMDERRKERREQREKEEIEKYR
MERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDGELDMRKIGQARNTLMD
MRLSQVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKSVR
ETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARL
QPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPN
SVRLWKAAVELEEPEDARIMLSRAVECCTSVELWLALARLETYENARKVL
NKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINR
EQWIQDAEECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAH
NALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAH
CPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLES
ENDEYERARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQDLCEEALR
HYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLE
EKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKA
LQECPNSGILWSEAIFLEARPQRRTKSVDALKKCEHDPHVLLAVAKLFWS
QRKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCES
AEPRHGELWCAVSKDIANWQKKIGDILRLVAGRI
Ligand information
>8h6j Chain 5A (length=114) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauu
uccguggagaggaacaacucugagucuuaacccaauuuuuugaggccuug
cuuuggcaaggcua
<<<.<<<<<<<<<<<<........<<<<<<<<...........>>>>>>>
>...>>>>>>>>>>>....>.>>>...................<<<<<<<
<....>>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8h6j Atomic structures of human exon-defined spliceosome prior to activation.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		R111 R116 R120
Binding residue
(residue number reindexed from 1)		R29 R34 R38
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030674 protein-macromolecule adaptor activity
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0006403 RNA localization
GO:0008380 RNA splicing
GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h6j, PDBe:8h6j, PDBj:8h6j
PDBsum8h6j
PubMed38658629
UniProtO94906|PRP6_HUMAN Pre-mRNA-processing factor 6 (Gene Name=PRPF6)

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