Structure of PDB 6qx9 Chain 4A Binding Site BS01

Receptor Information
>6qx9 Chain 4A (length=239) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEIEWWDSYIIFGITNLVEHPAQLNPPVTLGVYLTKKEQKKLRRQTRREA
QKELQEKVRLGLMPPPEPKPTKVEAHVRAQMAKRQKAHEEANAARKLTAE
QRKVKKIKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVV
VLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDTNKCVLVWEGTAKDRSFG
EMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD
Ligand information
>6qx9 Chain 6 (length=53) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuggaaaagauuagcauggccccugcgcaaggaugacuucgugaagcgau
uuu
..................................................
...
Receptor-Ligand Complex Structure
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PDB6qx9 Mechanism of 5' splice site transfer for human spliceosome activation.
Resolution3.28 Å
Binding residue
(original residue number in PDB)		K446 R449 R453 Q457 P474 K475 N515 R518 K519 L520 K528 P554 A555 F558 K559 N563 Q566 R596 R601
Binding residue
(residue number reindexed from 1)		K40 R43 R47 Q51 P68 K69 N92 R95 K96 L97 K105 P131 A132 F135 K136 N140 Q143 R173 R178
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0032991 protein-containing complex
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qx9, PDBe:6qx9, PDBj:6qx9
PDBsum6qx9
PubMed30975767
UniProtO43395|PRPF3_HUMAN U4/U6 small nuclear ribonucleoprotein Prp3 (Gene Name=PRPF3)

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