Structure of PDB 5el7 Chain 4A Binding Site BS01

Receptor Information
>5el7 Chain 4A (length=111) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEAEVVRLR
EYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQRTRTNA
RTRKGPRKTVA
Ligand information
>5el7 Chain 1G (length=1506) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaaga
caugcaagucgugcgggccgcgggguacuccguggucagcggcggacggg
ugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaa
cucgggcuaaucccccauguggacccgccccuugggguguguccaaaggg
cuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggggu
aauggcccaccaaggcgacgacggguagccggucugagaggauggccggc
cacaggggcacugagacacgggccccacuccuacgggaggcagcaguuag
gaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggagga
agaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacg
aggggacugacguaccgggguaauagcgccggccaacuccgugccagcag
ccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaa
gggcguguaggcggccuggggcgucccaugugaaagaccacggcucaacc
gugggggagcgugggauacgcucaggcuagacggugggagaggguggugg
aauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgaug
gcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcgugg
ggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgc
gcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgcc
gccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggc
ccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaacc
uuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccc
cgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugc
cgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuagu
ugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcggga
ggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgac
acacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggag
cuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgacc
ccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaa
uacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcu
cuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccg
ugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg
aucacc
.....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<
<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<
<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<.....
.>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<
<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<..
.....>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>
.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>.
.......<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<..
....<<<<....>>>>.....>>>>....<<<<<........<<<<....
.>>>>.........>>>>>......<<<<<(((...<<<<<.....<<.)
))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((...
..<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>
>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<..
..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........
<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<
...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<
<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.
>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<
<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>.......
...<<<<<<<.......<<<<<<...<<<<<<<....>>>>>>>......
............>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<
<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.
..<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>.
.......>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>
.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>
>....>>>.....>>>>>>>......<....<<<<<<<........>>>>
>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>...
...>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<
<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>
>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..
......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5el7 Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code.
Resolution3.15 Å
Binding residue
(original residue number in PDB)		K13 R14 V17 Y21 Y23 G24 I25 G26 A28 R29 R44 V74 N77 Y87 R91 H92 L96 P97 V98 R99 Q101 R102 T103 R104 T105 N106 A107 R108 T109 K111 R114 K115 T116
Binding residue
(residue number reindexed from 1)		K6 R7 V10 Y14 Y16 G17 I18 G19 A21 R22 R37 V67 N70 Y80 R84 H85 L89 P90 V91 R92 Q94 R95 T96 R97 T98 N99 A100 R101 T102 K104 R107 K108 T109
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5el7, PDBe:5el7, PDBj:5el7
PDBsum5el7
PubMed26791911
UniProtP80377|RS13_THET8 Small ribosomal subunit protein uS13 (Gene Name=rpsM)

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