Structure of PDB 5el5 Chain 4A Binding Site BS01

Receptor Information
>5el5 Chain 4A (length=111) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEAEVVRLR
EYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQRTRTNA
RTRKGPRKTVA
Ligand information
>5el5 Chain 1G (length=1496) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuuuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaa
gacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacg
ggugaguaacgcgugggugaccuacccggaagagggggacaacccgggga
aacucgggcuaaucccccauguggacccgccccuugggguguguccaaag
ggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggg
guaauggcccaccaaggcgacgacggguagccggucugagaggauggccg
gccacaggggcacugagacacgggccccacuccuacgggaggcagcaguu
aggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggag
gaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccga
cgaggggacugacgguaccgggguaauagcgccggccaacuccgugccag
cagccgcgguaauacggagggcgcgagcguuacccggauucacugggcgu
aaagggcguguaggcggccuggggcgucccaugugaaagaccacggcuca
accgugggggagcgugggauacgcucaggcuagacggugggagagggugg
uggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccg
auggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcg
uggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaug
cgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgc
gccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggg
ggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaaga
accuuaccaggccuugacaugcuagggaacccgggugaaagccuggggug
gcccuagcacaggugcugcauggccgucgucagcucgugccgugaggugu
uggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcggu
ucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggg
gacgacgucuggucagcauggcccuuacggccugggcgacacacgugcua
caaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaa
aaaggugggcccaguucggauuggggucugcaacccgaccccaugaagcc
ggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccg
ggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaag
ucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggc
gaagucguaacaagguagcuguaccggaaggugcggcuggaucacc
.......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..
<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>.....
.<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<...
...>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<
<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<
.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>
>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>
>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<
......<<<<....>>>>.....>>>>....<<<<<......<.<<<<..
...>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<
<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((
.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<....
.>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<
<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>........
...<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<
<<<...<<...<<<<.........>>>>...>>>>>>>>..........<
<<<<<..<<<<<<<<<.....>>>>>>>>>...<<..))>>.....>>>>
>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<
<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>....
......<<<<<<<...........<<<..<<<<<<<....>>>>>>>...
.>>>.......<<.<<<..<<<<<<.......<<<<<<<<<....>>>..
<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.
....>>>>......>>>>>>.....<<<<<....>>>>>........>>>
>.........>>>...>>>>>>>>....>>>>>>>......>>>>>>>>.
....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>..
...>>>>>>>...........<<<<<<<........>>>>>>>.......
...>>>>>>....<<<<<<<..........>>>>>>>......>>...>>
>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<
.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>
>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........
Receptor-Ligand Complex Structure
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PDB5el5 Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code.
Resolution3.15 Å
Binding residue
(original residue number in PDB)		K13 R14 Y21 Y23 G24 I25 G26 K27 A28 R29 R44 V74 N77 Y87 R88 L96 V98 R99 Q101 R102 T103 R104 T105 N106 A107 R108 T109 K111 R114 K115 T116
Binding residue
(residue number reindexed from 1)		K6 R7 Y14 Y16 G17 I18 G19 K20 A21 R22 R37 V67 N70 Y80 R81 L89 V91 R92 Q94 R95 T96 R97 T98 N99 A100 R101 T102 K104 R107 K108 T109
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5el5, PDBe:5el5, PDBj:5el5
PDBsum5el5
PubMed26791911
UniProtP80377|RS13_THET8 Small ribosomal subunit protein uS13 (Gene Name=rpsM)

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