Structure of PDB 8jd4 Chain 4 Binding Site BS01

Receptor Information
>8jd4 Chain 4 (length=756) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRIN
NDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIRVVGVIGASGSSV
SIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVD
IVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPK
AGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGS
DSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIW
FAEFWEDNFHCKLVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALH
AMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDA
PGRYDIYQYQLRAEYKVIGSWTDHLHLRIERMHWQQLPRSICSLPCQPGE
RKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPI
IKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYV
LLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIY
RIFEISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRF
ARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGTFNEAKPIGFTMY
TTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKV
YIILFH
Ligand information
Ligand IDGLU
InChIInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKeyWHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370N[CH](CCC(O)=O)C(O)=O
FormulaC5 H9 N O4
NameGLUTAMIC ACID
ChEMBLCHEMBL575060
DrugBankDB00142
ZINCZINC000001482113
PDB chain8jd4 Chain 4 Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8jd4 Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Resolution2.9 Å
Binding residue
(original residue number in PDB)
K74 R78 S157 S159 A180 S181 T182 Y230 D312 S313 K317
Binding residue
(residue number reindexed from 1)
K34 R38 S96 S98 A119 S120 T121 Y169 D251 S252 K256
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0008066 glutamate receptor activity
GO:0044877 protein-containing complex binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
GO:0007216 G protein-coupled glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0043410 positive regulation of MAPK cascade
GO:0043523 regulation of neuron apoptotic process
GO:0051966 regulation of synaptic transmission, glutamatergic
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0045202 synapse
GO:0098793 presynapse

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:8jd4, PDBe:8jd4, PDBj:8jd4
PDBsum8jd4
PubMed37286794
UniProtA0A8V8TRG9;
Q14833|GRM4_HUMAN Metabotropic glutamate receptor 4 (Gene Name=GRM4)

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