Structure of PDB 7zdm Chain 4 Binding Site BS01

Receptor Information

>7zdm Chain 4 (length=430) Species: 9940 (Ovis aries)

ARQWQPDVEWAEQYGGAVMYPTKETAHWKPPPWNDVDPPKDTLVSNLTLN
FGPQHPAAHGVLRLVMELSGEMVRKCDPHIGLLHRGTEKLIEYKTYLQAL
PYFDRLDYVSMMCNEQAYSLAVEKLLNIQPPPRAQWIRVLFGEITRLLNH
IMAVTTHALDIGAMTPFFWMFEEREKMFEFYERVSGARMHAAYVRPGGVH
QDLPLGLMDDIYEFSKNFSLRIDELEEMLTNNRIWRNRTVDIGVVTAEDA
LNYGFSGVMLRGSGIQWDLRKTQPYDVYDQVEFDVPIGSRGDCYDRYLCR
VEEMRQSIRIISQCLNKMPPGEIKVDDAKVSPPKRAEMKTSMESLIHHFK
LYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPYRCKIKAPGFAHLA
GLDKMSKGHMLADVVAIIGTQDIVFGEVDR

Ligand information

• Ligand ID: SF4
• InChI: InChI=1S/4Fe.4S
• InChIKey: LJBDFODJNLIPKO-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 2.0.7: [S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
  CACTVS 3.385: S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
• Formula: Fe4 S4
• Name: IRON/SULFUR CLUSTER
• PDB chain: 7zdm Chain 6 Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7zdm A universal coupling mechanism of respiratory complex I.
• Resolution: 3.44 Å
• Binding residue (original residue number in PDB): R105 H190
• Binding residue (residue number reindexed from 1): R105 H190
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0016651 oxidoreductase activity, acting on NAD(P)H
• GO:0048038 quinone binding
• GO:0051287 NAD binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0006120 mitochondrial electron transport, NADH to ubiquinone

Cellular Component

• GO:0005739 mitochondrion

External links

• PDB: RCSB:7zdm, PDBe:7zdm, PDBj:7zdm
• PDBsum: 7zdm
• PubMed: 36104567
• UniProt: A0A6P3DZ89