Structure of PDB 7w1y Chain 4 Binding Site BS01

Receptor Information
>7w1y Chain 4 (length=653) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VRGTPVRQRPDLGSAQKGLQVDLQSKLVIWGTDVNVAACKENFQRFLQRF
IDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLY
RQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRN
LNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIA
EPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILF
AHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRK
TDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEH
EDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYV
YNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCI
DEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQ
WNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQS
LLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVSAY
PRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGI
VDI
Ligand information
>7w1y Chain O (length=49) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
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PDB7w1y The human pre-replication complex is an open complex.
Resolution2.59 Å
Binding residue
(original residue number in PDB)		K549 E581
Binding residue
(residue number reindexed from 1)		K426 E458
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016020 membrane
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7w1y, PDBe:7w1y, PDBj:7w1y
PDBsum7w1y
PubMed36608662
UniProtP33991|MCM4_HUMAN DNA replication licensing factor MCM4 (Gene Name=MCM4)

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