Structure of PDB 7pnw Chain 4 Binding Site BS01

Receptor Information

>7pnw Chain 4 (length=589) Species: 10090 (Mus musculus)

EEIVIPKKKTWDKVAVLQALASTVNRDPTAAPYVFHDDPYLIPTSALESR
SFLLAKKSGETAAKFIINSYPKYFQKDIAEPHIPCLMPEYFEPQIEDVSE
AALEERIRLRKVRASVDMFDQLLQAGTTVSLETTNSLLDLLCYYGDQEPP
ADYPGPWKAQNNAERIFALMPEKNARSYCTMIRGMVKHRAYAQALNVYTE
LLNNRLSADVYTFNALIEAKTFILNEKFEEKWNDILDLLKHMVAQKVKPN
LQTFNTILKGLRKCYSLGRIPALQILREMKHIGIEPSLATYHHIIHLFYP
RDLSAIKMPSLIIYDIMNELEGRTFSPQDLDDGRFFQLAMSVCSSLRDLE
LAYQVHRLLNTGDNRKLVGHDPLRKVYYSKFFSLICSLEQIDVTLKWYKD
LIPSVFLPHYQIFIGLLQALDVANRLELVPQIWKDSKEYSHTFRDALREE
VLMLMARDKHPPELQVAFADCAADIKSTYEDQSARQPAFDWPANPLQYIA
VLFLRGGRSQEAWKMLELFKKHKKIPRNELLEEFMDTAKASGSTALAIEV
VKLASAFSLPIGESLAQRVVMDFTVDPEQKEALGNLTEL

Ligand information

>7pnw Chain A (length=954)

aaagguuugguccuggccuuauaauuaauuagagguaaaauuacacaugc
aaaccuccauagaccgguguaaaaucccuuaaacauuuacuuaaaauuua
aggagaggguaucaagcacauuaaaauagcuuaagacaccuugccuagcc
acacccccacgggacucagcagugauaaauauuaagcaauaaacgaaagu
uugacuaaguuauaccucuuaggguugguaaauuucgugccagccaccgc
ggucauacgauuaacccaaacuaauuaucuucggcguaaaacgugucaac
uauaaauaaauaaauagaauuaaaauccaacuuauaugugaaaauucauu
guuaggaccuaaacucaauaacgaaaguaauucuagucauuuauaauaca
cgacagcuaagacccaaacugggauuagauaccccacuaugcuuagccau
aaaccuaaauaauuaauuaacaaaacuauuugccagagaacuacuagcca
uagcuuaaaacucaaaggacuuggcgguacuuuauauccaucuagaggag
ccuguucuauaaucgauaaaccccgcucuaccucaccaucucuugcuaau
ucagccuauauaccgccaucuucagcaaacccuaaaaagguauuaaagua
agcaaaagaaucaaacauaaaaacguuaggucaagguguagccaaugaaa
ugggaagaaaugggcuacauuuucuuauaaaagaacauuacuauacccuu
uaugaaacuaaaggacuaaggaggauuuaguaguaaauuaagaauagaga
gcuuaauugaauugagcaaugaaguacgcacacaccgcccgucacccucc
ucaaauuaaauuaaacuuaacauaauuaauuucuagacauccguuuauga
gaggagauaagucguaacaagguaagcauacuggaaagugugcuuggaau
aauc

..((((..<<<<<<.)))).<<<<<<<.<..<<<<<<<<..<.<<<.<<<
..<......>......<<......<<<<<<<<<..<<<<..>>>>.>>>>
>>>.>>.<<<....<<...<<....>>..>>......>>>..<<...>>.
>>.<<<....>>>.....>>>>>>>.........<<....<<<<....>>
>>..>>...>>.>>>>>>...<<<<<<<<.....(((.....((.>>>))
.......)))..>>>>>..>.>>>>>>>....<<<((.....<<<<....
<<............<<<<<<....<<<<<<<....<<......>>.....
>>>.>>>..>..........<<....>>.>>>>>>......>>....>>>
>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>...
.......<<<<.<<.....))..>>.>>>>.>>>.<<<.......<<<..
..>>>.....>>>..>>>>>><<<<<.<<<<<<....<...<<<<<..<<
<<<<<<<<.....<<........>>..........<<<<.<<........
...<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>>.
.>>......<<.....>>..........>>>...>>>>>>>>....>>.>
>>>..>>.>>>>>>>>.....<<<<<....>>>>>.....<<..<.<<<<
<<......>>>>>>..>.>>.....>>>>>.....<<<<<<<........
.>>>>>>>.......>....>>>>>>>>>.>>....<..<<.<...<<<<
<<..<.<<<<<....<<....<<.....>>....>>......>>>>>>..
>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>.....
....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7pnw Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
• Resolution: 3.09 Å
• Binding residue (original residue number in PDB): K127 Y128
• Binding residue (residue number reindexed from 1): K72 Y73

Gene Ontology

Molecular Function

• GO:0019843 rRNA binding
• GO:0043024 ribosomal small subunit binding

Biological Process

• GO:0006417 regulation of translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0005886 plasma membrane
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7pnw, PDBe:7pnw, PDBj:7pnw
• PDBsum: 7pnw
• PubMed: 35676484
• UniProt: Q14C51|PTCD3_MOUSE Small ribosomal subunit protein mS39 (Gene Name=Ptcd3)