Structure of PDB 7of3 Chain 4 Binding Site BS01

Receptor Information

>7of3 Chain 4 (length=37) Species: 9606 (Homo sapiens)

FKNKTVLKKRCKDCYLVKRRGRWYVYCKTHPRHKQRQ

Ligand information

>7of3 Chain A (length=1386)

gcuaaaccuagccccaaaccccaccuuacuaccagacaaccuuagccaaa
ccauuuacccaaauaaaguauaggcgauagaaauugaaauggcgcaauag
auauaguaccgcaagggaaagaugaaaaacaagcauaauauagcaaggac
uaaccccuauaccuucugcaaugaauuaacuagaaauaacuuugcaagga
gagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcua
aaagagcacacccgucuauguagcaaaauagugggaagauuuauagguag
aggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaau
cuuaguucaacuuuaaauuugcccacagaacccaaauccccuuguaaauu
uaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccu
uguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagcca
ccaauuaagaaagcguucaagcucaacacaaaaaucccaaacauauaacu
gaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaa
uguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguca
gauacugacaauuaacagcccaauaucuacaaucaaccaacaagucauua
uuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaa
aaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaaca
ucaccucuagcaucaccaguauuagaggcaccgccuuccuuaaauaggga
uggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugac
cugcccgugagaggcgggcauaacacagcaagacgagagacccuauggag
cuuuaauuuauuaaugcaaacaaccugcauuaaaaauuucgguuggggcg
accucggagcagaacccaaccuccgagcaguacaugcuaagacuucacca
gucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguua
cccuagggaaauccuauucuagaguccauaucaacaauaggguuuacgac
cucguuggaucaggacaucccgauggugcagccgcuauuaaagguucguu
uguucaacgauuaaaguccuacgugaucugaguucagaccggaguaaucc
aggucgguuucuaucuacuuuaauuccucccuguacgaaaggacaagaga
aauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucuca
acuuaguauuauacccacacacccaagaacaggguu

<<<.......<<<<.................................<..
....>...............<<.....>>...........>>.>>.....
........<<....>>...............>>>...........<<<..
.....>>>...<.<<....>>.>.<<<<<<.........<<<.<<..<<.
...>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.
....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>..
.<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<
....>>>><<<.<<<<<<<<<<.....<<.......>>.....>>>>>>>
>>>..>>>.<<<<<<<<<<....[.>>>>>>>>>>...<<<......>>>
....<<<.<<<...<..............<....<<<.........>>>.
...>.......<<<......>>>..........................>
...>>>>>>........>>>>>>...<<<<<......>>>>>........
.>>>>>>.......<<..<<<....>>><<<<..<<<<........<<<<
<...>>>>>......<<<...<<<<.......................>>
>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...
<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>
...<<<<<<.............>>>>>>....<<<.<<<<.....>>>>.
.>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.........
..<<<<<.......>>>>>.......<<..<<<.<<<...<<<<<.<<<<
<<..<<<<<.<<<<<<<<.......>>>>>>>>>>>>>..<<<<((((.>
>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>
>>>..>>>....>>.........<<<....>>>............>>>>.
.>>>>>>>.<<<<<<<<<...<<.......>>...>>>>>>>>>]....)
))).<<<<<..<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<
.....>>>>>.....>>>>>......>>>>>.....<<<<<<<....>>>
.>>>>...>>>..>>>.>>...<<<.<<<.................>>>.
>>><<<<<...<<<....>>>.>>>>>......<<<..............
..>>>...............<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7of3 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): F66 N68 K69 T70 L72 K74 R75 K77 K83 R84 R85 G86 W88 Y89 Y91 P96 R97 K99 R101
• Binding residue (residue number reindexed from 1): F1 N3 K4 T5 L7 K9 R10 K12 K18 R19 R20 G21 W23 Y24 Y26 P31 R32 K34 R36

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:0016604 nuclear body
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7of3, PDBe:7of3, PDBj:7of3
• PDBsum: 7of3
• PubMed: 34135319
• UniProt: Q9P0J6|RM36_HUMAN Large ribosomal subunit protein bL36m (Gene Name=MRPL36)