Structure of PDB 7o73 Chain 4 Binding Site BS01

Receptor Information
>7o73 Chain 4 (length=293) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESPSLLTVIIEIAPKLWTTFDEEGNEKGSIIKVLEALIVFLNAHLAFNSA
NKVAVIAAYSQGIKYLYPESTSDLKIINSDMYRRFRNVDETLVEEIYKLF
ELEKKQIEQNSQRSTLAGAMSAGLTYVNRISKESVSLKSRLLVLTCGSGS
SKDEIFQYIPIMNCIFSATKMKCPIDVVKIGGSKESTFLQQTTDATNGVY
LHVESTEGLIQYLATAMFIDPSLRPIIVKPNHGSVDFRTSCYLTGRVVAV
GFICSVCLCVLSIIPPGNKCPACDSQFDEHVIAKLKRKPVVPR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7o73 Chain 4 Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7o73 Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C289 C292 C305 C308
Binding residue
(residue number reindexed from 1)		C254 C257 C270 C273
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006355 regulation of DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
Cellular Component
GO:0000112 nucleotide-excision repair factor 3 complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005675 transcription factor TFIIH holo complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7o73, PDBe:7o73, PDBj:7o73
PDBsum7o73
PubMed34133942
UniProtQ12004|TFB4_YEAST General transcription and DNA repair factor IIH subunit TFB4 (Gene Name=TFB4)

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