Structure of PDB 6zsc Chain 4 Binding Site BS01

Receptor Information

>6zsc Chain 4 (length=38) Species: 9606 (Homo sapiens)

FKNKTVLKKRCKDCYLVKRRGRWYVYCKTHPRHKQRQM

Ligand information

>6zsc Chain XA (length=1500)

gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcaua
auauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaa
auaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcu
accuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggg
aagauuuauagguagaggcgacaaaccuaccgagccuggugauagcuggu
uguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccaa
auccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggac
acuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguag
gccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaa
ucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucac
ccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccucc
gcauaagccugcgucagauaaccaacugacaauuaacagcccaauaucua
caaucaaccaacaagucauuauuacccucacugucaacccaacacaggca
ugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuac
cccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggc
accgccugcccagugacacauguuuaacggccgcgguacccuaaccgugc
aaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcu
ccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcc
cgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuu
uaauuuauuaaugcaaacaguaaccaaaccugcauuaaaaauuucgguug
gggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuu
caccagucaaagcgaaccucaauugauccaauaacuugaccaacggaaca
aguuacccuagggauaacagcgcaauccuauucuagaguccauaucaaca
auaggguuuacgaccucgauguuggaucaggacaucccgauggugcagcc
gcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugagu
ucagaccggaguaauccaggucgguuucuaucuacuuauuccucccugua
cgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccgua
aaugauaucaucucaacuuagaauacccacacccacccaagaacaggguu

<<<.......<<<<....................................
.<......>.........<.....<<.....>>....>........>>.>
>.............<<....>>......................>>>...
........<<<.......>>>...<.<........>.>.<<<<<<.....
....<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....
<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>
....>>>.>>>>>...<<.......>>......>.>>>>......>.>>.
.<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......
.>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>
...<<<......>>>....<<<.<<<...<..............<....<
<<.........>>>....>.......<<<......>>>............
...............>...>>>>>>........>>>>>>...<<<<<...
...>>>>>.........>>>>>><......<<..<<<....>>><<<<..
<<<<........<<<<<........>>>>>......<<<...<<<<....
...................>>>>.......>>>.....<<......>>.>
>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<
<<<<..<<<.........>>>...<<<<<<.............>>>>>>.
...<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>.
.......<...........<<<<<<.....>>>>>>.....>....>>>.
...>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<
<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<.
.<<<<<.<<<<<<<<...............>>>>>>>>>>>>>..<<<<.
....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.
....>>>>..>>>....>>.........<<<....>>>............
>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>
>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......
>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>.
...<<<<<<<....>>>.>>>>....>>..>>>.>>.<<<.<<<......
...........>>>.>>><<<<<...<<<....>>>.>>>>>......<<
<................>>>..............<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zsc Structural basis of mitochondrial translation.
• Resolution: 3.5 Å
• Binding residue (original residue number in PDB): F66 N68 K69 T70 V71 K74 R75 L81 K83 R84 R85 W88 Y89 Y91 P96 R97 K99 R101 M103
• Binding residue (residue number reindexed from 1): F1 N3 K4 T5 V6 K9 R10 L16 K18 R19 R20 W23 Y24 Y26 P31 R32 K34 R36 M38

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:0016604 nuclear body
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zsc, PDBe:6zsc, PDBj:6zsc
• PDBsum: 6zsc
• PubMed: 32812867
• UniProt: Q9P0J6|RM36_HUMAN Large ribosomal subunit protein bL36m (Gene Name=MRPL36)