Structure of PDB 6ray Chain 4 Binding Site BS01

Receptor Information
>6ray Chain 4 (length=617) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TNVVVSQCKSKFKSFIMRFIDPSAEQDEISENIDVNQPLYLQKLEEIHTL
EEPYLNLNCAHLKTFDQDLYRQLICYPQEVIPGFDMAINEMFFERYPAAL
LEHQIQFNADKTRNMRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSC
NICSFSTTVEVDRGRINQPTLCTNCNTNHCFRLIHNRSEFTDKQLVKLQE
SPDDMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSS
SVKSVYKTHVDVVHFRKVDNKRLYEDEEGKDHIFPPERVELLQLLAKKPD
IYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHATLGRQNFRSEIHLL
LCGDPGTSKSQMLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLV
LQTGALVLADNGVCCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICQL
NARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIFLVLDPQDEI
FDKRLASHLVSLYYVTRHEEEDTMFDMSVLRDYIAYAREHLSPTLSDEAQ
QRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLD
VEEAWRLHREALKQSAT
Ligand information
Receptor-Ligand Complex Structure
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PDB6ray Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.
Resolution4.28 Å
Binding residue
(original residue number in PDB)		V543 Y548 K602
Binding residue
(residue number reindexed from 1)		V384 Y389 K443
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0007052 mitotic spindle organization
GO:0032508 DNA duplex unwinding
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0005634 nucleus
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ray, PDBe:6ray, PDBj:6ray
PDBsum6ray
PubMed31484077
UniProtQ26454|MCM4_DROME DNA replication licensing factor MCM4 (Gene Name=dpa)

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