Structure of PDB 4wfa Chain 4 Binding Site BS01

Receptor Information
>4wfa Chain 4 (length=37) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKVRPSVKPICEKCKVIKRKGKVMVICENPKHKQRQG
Ligand information
>4wfa Chain X (length=2711) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gauuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccaau
gaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuu
gauccagagauuuccgaauggggaaacccagcaugaguuaugucauguua
ucgauauguauacauagcauaucagaaggcacacccggagaacugaaaca
ucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggc
gagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguugag
gacacucuaugaguuacaaaggacgacauuagacgaaucaucuggaaaga
ugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuuga
guggauccugaguacgacggagcacgugaaauuccgucggaaucugggag
gaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccagua
ccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccu
gaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgug
ccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcag
uaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuu
ggucguagacccgaaaccaggugaucuacccuuggucagguugaaguuca
ggcugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaac
ugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuc
cgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagca
cuguuuggacgaggggguuaccgaauucagacaaacuccgaaugccaauu
aauuuaacuugggagucagaacaugggugauaagguccguguucgaaagg
gaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaa
aaggauguggcguugcccagacaacuagcucacuagucgagugacacugc
gccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguccu
uggacaaugguaggagagcguucuaagggcguugaagcaugaucguaagg
acauguggagcgcuuagaagugagaaugccggugugaguagcgaaagacg
ggugagaaucccguccaccgauugacuaagguuuccagaggaaggcucgu
ccgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgau
ggauaacagguugauauuccuguaccaccuauaaucguaucgaugggggg
acgcaguaggauaggcgagcgugcgauuggaugcacgucuaagcaguagg
cugaguaaaauccgguacucggcugagcugugauggggagaagagagucg
uugauuucacacugccgagaaaagccucuagauagaauaggugcccguac
cgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcga
acucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggg
gugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaagc
gacuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguaua
ggggcugacgccugcccgugcuggagguuaagaggagugguuagcugcga
agcuacgaaucgaagccccaguaaacggcggccuaagguagcgaaauucc
uugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacug
ucucaacgagagacucggugaaaucauaguaccugugaagaugcagguua
cccgcgacaggacggaaagaccccguggagcuuuacuguagccugauauu
gaaauucuggcuuucuaacccgcaccacuuaucguggugggagacagugu
caagcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggc
gcucaaagguucccucagaaugguuggaaaucauucauagaguguaaagg
cauaagggagcuugacugcgagaccuacaagucgagcagggucgaaagac
ggacuuagugauccggugguuccgcauggaagggccaucgcucaacggau
aaaagcuaccccggggauaacaggcuuaucucccccaagaguucacaucg
acggggagguuuggcaccucgaugucggcucaucgcauccuggggcugua
gucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcug
gguucagaacgucgugagacaguucggucccuauccgucgugggcguagg
aaauuugagaggagcuguccuuaguacgagaggaccgggauggacauacc
ucugguguaccaguugucgugccaacggcauagcuggguagcuaugugug
gacgggauaagugcugaaagcaucuaagcaugaagccccccucaagauga
gauuucccaacuugguuauaagaucccucaaagaugaugagguuaauagg
uucgagguggaagcauggugacauguggagcugacgaauacuaaucgauc
gaagacuuaau
..<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<...
...<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>...
..>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.
<<<<<<<<<.......>>>>>>>.>>.>>....<<<<<......<<....
>>.......>>>>.>.........<<....>>..<<<<<......<<...
..>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>.....<<
<<<<<<<...<..........<<<<<<<<<.<<<...<<<<<......>>
>>>((......<<<.....))>>>...>>>...>>>>>>>>.>...>.>>
>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<
..<<<<>>>>>..)))......]].>>>>>>>.]]...............
<<....>>....]].........<<<<....>>>>...............
...>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...
<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<..
.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.
>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<.
....>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>
>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<
<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<..
.<<<<<<<<...<<......>>...>>>>>>>>..>>.>.....>>>>.>
>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<
<......>>>...<<<<.<<<...<<<(((.....<<<<<<.........
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.>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>
.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<
<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....
>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...
>>...<<<<<........>>>>>))<<<<<<<......<<<...<<<<..
..<<<<...<<...<...<.<<<...{.{..>>>.>.<....<<<<<.<<
<.<<.<..........>.>>.>>>..>>>>>.....>.............
.>....>>...>>>>.........>>>.>.>>>...>>>>>>>>>>>..>
>.....<<......>>>>>>>.<<<<....>.>>>..>>>>..<<<<...
.<<<<<<<<.<<...............<<<<<.....<..>......>>>
>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<
<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>
>>>>>>.<<<<<..<<.<<<<<<<.<<<...<<...<<<<<..<<.>>..
.>>>>>...>>...>>>>>>>>..>>>>............<.........
..<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>....
.>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..
<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<.<<<<<<.
<<<<.......>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>
>>.>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>
..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>
>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>
.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>..........
...>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>.
..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<...
...>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.
>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<
<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<.
..<<<<...<<<<<<<<<<<.}.}>>>>>>..>>>>>...>>>>.>>>>>
...<<<....<<<<<...........>>>>>....>>>.>>>>.......
>>>>>>>.<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<
<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>
....>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4wfa Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.
Resolution3.392 Å
Binding residue
(original residue number in PDB)
M1 K2 V3 R4 P5 S6 V7 K8 I10 K18 R19 P30 K31 K33 R35 Q36
Binding residue
(residue number reindexed from 1)
M1 K2 V3 R4 P5 S6 V7 K8 I10 K18 R19 P30 K31 K33 R35 Q36
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:4wfa, PDBe:4wfa, PDBj:4wfa
PDBsum4wfa
PubMed26464510
UniProtQ2FW29|RL36_STAA8 Large ribosomal subunit protein bL36 (Gene Name=rpmJ)

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