Structure of PDB 5wyk Chain 3E Binding Site BS01

Receptor Information
>5wyk Chain 3E (length=382) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YVLTETSAGYALLKASVLKEFKIAAFSKFNSAANALEEANSIIEGKVSSQ
LEKLLEEIKKDKKSTLIVSETKLANAINKLGLNFNVVSDAVTLDIYRAIK
EYLPELLPGMSDNDLSKMSLGLAHSIGRHKLKFSADKVDVMIIQAIALLD
DLDKELNTYAMRCKEWYGWHFPELAKIVTDSVAYARIILTMGIRSKASET
DLSEILPEEIEERVKTAAEVSMGTEITQTDLDNINALAEQIVEFAAYREQ
LSNYLSARMKAIAPNLTQLVGELVGARLIAHSGSLISLAKSPASTIQILG
AEKALFRALKTKHDTPKYGLLYHASLVGQATGKNKGKIARVLAAKAAVSL
RYDALAEDRDDSGDIGLESRAKVENRLSQLEG
Ligand information
>5wyk Chain 3A (length=157) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gucgacguacuucauaggaucauuucacucuuugacucuucaaaagagcc
acugaauccaacuugguugaugaccuuuguaccccagagugagccguugc
auuuuauggcgcgaugaucuugacccauggguggguacaaauggcagucu
gacaagu
..................................................
..........<<<<<........<<<<<<<<<<<....<....<<<<.<.
...>.>>>>.........>...<<<<..>>>>>>>>>>>>>.>>......
..>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5wyk Molecular architecture of the 90S small subunit pre-ribosome.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		T316 L320 K324 F327 D335 T336 K338 K358 R361 V362 A365 K366
Binding residue
(residue number reindexed from 1)		T295 L299 K303 F306 D314 T315 K317 K337 R340 V341 A344 K345
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0017069 snRNA binding
GO:0030515 snoRNA binding
Biological Process
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000452 snoRNA guided rRNA 2'-O-methylation
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000494 box C/D sno(s)RNA 3'-end processing
GO:0006364 rRNA processing
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
GO:1902570 protein localization to nucleolus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0030686 90S preribosome
GO:0031428 box C/D methylation guide snoRNP complex
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5wyk, PDBe:5wyk, PDBj:5wyk
PDBsum5wyk
PubMed28244370
UniProtQ12499|NOP58_YEAST Nucleolar protein 58 (Gene Name=NOP58)

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