Structure of PDB 8w7m Chain 3 Binding Site BS01

Receptor Information
>8w7m Chain 3 (length=619) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDNILPHRIII
SLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDDVPHPNASAVS
SRHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIR
SVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYS
TFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVF
KSLGAGGMNQSNSNTLIGFKTLILGNTVYPLHAARQMLTDFDIRNINKLS
KKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDIN
ILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDERRLE
AGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNA
RCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRD
RSISEHVLRTHRYLPPGYLEGEPVRPKLVTIPFLRKYVQYAKERVIPQLT
QEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKTVN
KVDAKVAANLLRFALLGED
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8w7m Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Resolution4.12 Å
Binding residue
(original residue number in PDB)		V446 K499 A500
Binding residue
(residue number reindexed from 1)		V392 K441 A442
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:1904931 MCM complex binding
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0030466 silent mating-type cassette heterochromatin formation
GO:0031509 subtelomeric heterochromatin formation
GO:0032508 DNA duplex unwinding
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8w7m, PDBe:8w7m, PDBj:8w7m
PDBsum8w7m
PubMed37730685
UniProtP24279|MCM3_YEAST DNA replication licensing factor MCM3 (Gene Name=MCM3)

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