Structure of PDB 8om2 Chain 3 Binding Site BS01

Receptor Information

>8om2 Chain 3 (length=257) Species: 4932 (Saccharomyces cerevisiae)

IHVVPKLPNSKALLQNGVPNILSSSGFKTVWFDYQRYLCDKLTLATAGQS
LESYYPFHILLKTAGNPLQSNIFNLASSIHNNHLFVENILPSAVEHGTNS
NAVVKTEPSRLFLSKIKDSFNGSDWEVVKEEMIYRAENEVLGQGWLFLVE
NNEKKLFILTSNNNGTPYYFPRNQSFDLNSAISIDEFATLKQMKELIGKS
TKLNGKVQDWTMPIICVNLWDHAYLHDYGVGNRSKYVKNVLDNLNWSVVN
NRIFSGI

Ligand information

>8om2 Chain r (length=1486)

auaagaauaugauguugguucagauuaagcgcuaaauaaggacaugacac
augcgaaucauacguuuauuauugauaagauaauaaauaugugguguaaa
cgugaguaauuuuauuaggaauuaaugaacuauagaauaagcuaaauacu
uaauauauaaaaaggauauauaauauauuuaucuauagucaagccaauaa
ugguuuagguaguagguuuauuaagaguuaaaccuagccaacgauccaua
aucgauaaugaaaguuagaacgaucacguugacucugaaauauagucaau
aucuauaagauacagcagugaggaauauuggacaaugaucgaaagauuga
uccaguuacuuauuaggaugauauauaaauauauauauauaaauugauua
aaaauaaaauccauaaauaauuaaaauaaugauauuaauuaccauauauu
uuuauauggauauauuuuaauaguccugacuaauauuugugccagcaguc
gcgguaacacaaagagggcgagcguuaaucauaaugguuuaaaggauccg
uagaaugaauuauauauuauaauuuagaguuaauaaaauuaauuaaagaa
uuauaauaguaaagaugaaauaaauaauuauaagacuaauauaugugaaa
auauuaauuaaauauuaacugacauugagggauuaaaacuagaguagcga
aacggauucgauacccguguaguucuaguaguaaacuaugaauacaauua
uuuauauauauauauauaaauaauaaaugaaaaugaaaguauuccaccug
aagaguacguuagcaauaaugaaacucaaaacaauagacgguuacagacu
uaagcaguggagcauguuauuuaauucgauaauccacgacuaaccuuacc
auauuuugaauauuauaauaauuaaauuauuauauuacaggcguuacauu
guugucuuuaguucgugcugcaaaguuuuagauuaaguucauaaacgaac
aaaacuccauauauauaauuuuaauuauauauaauuuuauauuauuuauu
aauauaaagaaaggaauuaagacaaucauaaugauccuuauaauaugggu
aauagacgugcuauaauaaaaugauaauaaaauuauauaaaauauauuua
auuauauuuaauuaauaauauaaaacauuuuaauuuuuaauauauuuuuu
uauuauauauuaauaugaauuauaaucugaaauucgauuauaugaaaaaa
gaauugcuaguaauacguaaauuaguauguuacggugaauauucuaacug
uuucgcacuaaucacucaucacgcguugaaacauauuauuaucuuauuau
uuauauaauauuuuuuaauaaauuuauuaauuuauauuuauuuauaucag
aaauaauaugaauuaaugcgaaguugaaauacaguuaccguaggggaacc
ugcggugggcuuauaaauaucuuaaauauucuuaca

....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<
.<<<..<<<..<<<<<<<<<<<<.....>>>>>>>>>>..>>>>>.....
<<<........<<<<<.<<.........<<<<<<<<.<<<<.......>>
>>...........<<<<<<<<.>>>>>>>>.>>>>>>>>....>>>>>>>
<<<....<<<..<<<<<<<<........>>>>>>>>>>>......>>>..
<<<<.<<<<....>>>>...>>>>.>>><<<<<<.........>>>>>><
<<<.....>>>>..>>>>>>.........<<<....<<<<....>>>>..
>>>..>>.>>>>>>.<<<<..<<<<<<........>>>>>>..<<.....
.>>.....>>>>..<<<<<<<<..............>>>>><<<<<<<..
..>>>>>>><<..>>>>>....<<<<<(((.....<<<<.....<<.)))
>>.......>>>>.>>>>>..>>>>>>>>>.....<<<((.....<<<<.
..<.<<.<<<<<<<...>>>>>>>...<<<<<<<<...<<<<<<<<<<..
<<<<<<<...................>>>>>>>..>>.......<<....
>>.>>>>>>>>.>>>>>>>>...>>>...>>>>....<<<<<<...<<..
.<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<
<<<<<<<<<..>>>>>>>>>>>>>..<<..))>>....>>>>>>.>>>.<
<.......<<<<....>>>>.....>>..)))).]<<.<<...<<<<...
.<.<<<<<..<<<<<<<<<<............................<<
<<<<<.....<<.<<<<<<<<<<.>>>>>>>>>>.>>.<<<.<<..<<<<
<<<<<<<<..<<<<<<<<<....>>>....<<......>>....>>>>>>
.....<<<.<<<<<<<<........>>>>>>>>..<<<<<<<<<.....>
>>>>>>>>....>>>...>>>>>>>...>>>>>>>>>>...>>>>>>>..
.>>.>>>>>>>>.....<<<<<<........<<<..<<..<<<<<<....
..>>>>>>..>>....>>>......>>>>>>......<<<<<........
>>>>>..........<....<<<<<<<........>>>>>>>....>...
..>>>>>.....<<.<<<<<.........>>>>>>>.....>.....>>>
>..>>..>>....<.<<<.<.<<<<<<<<..<<<<<<<<<.<<<...<<<
..<<<.<<<<<...<<<<<<<..>>>>>>>...>>>>>>>>..>>>..>>
>>>>>>>>>>..>>>>>>>>..>.>>>..>.....<<<<<<<<<....>>
>>>>>>>.............................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8om2 METTL17 is an Fe-S cluster checkpoint for mitochondrial translation.
• Resolution: 2.57 Å
• Binding residue (original residue number in PDB): Y61 F64 H65 K69 N73 Q76 Y175 W217
• Binding residue (residue number reindexed from 1): Y54 F57 H58 K62 N66 Q69 Y168 W210

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0004784 superoxide dismutase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006801 superoxide metabolic process
• GO:0019430 removal of superoxide radicals
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8om2, PDBe:8om2, PDBj:8om2
• PDBsum: 8om2
• PubMed: 38199006
• UniProt: P47141|RT26_YEAST Small ribosomal subunit protein mS42 (Gene Name=RSM26)