Structure of PDB 8kg9 Chain 3 Binding Site BS01

Receptor Information
>8kg9 Chain 3 (length=637) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANLNILPHRIIISL
DDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDDVPHPNASAVSSR
HPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSV
HYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTF
IDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKS
LGAGGMNQSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINK
LSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGD
INILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRET
GERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGI
HTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDD
INEIRDRSISEHVLRTHRYLPPGYLEGEPVRERLNLSLAVGEDADKLVTI
PFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLE
TLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALLGE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8kg9 Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Resolution4.52 Å
Binding residue
(original residue number in PDB)		V440 G441 V446 T447 R455 K499
Binding residue
(residue number reindexed from 1)		V388 G389 V394 T395 R403 K447
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:1904931 MCM complex binding
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0030466 silent mating-type cassette heterochromatin formation
GO:0031509 subtelomeric heterochromatin formation
GO:0032508 DNA duplex unwinding
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8kg9, PDBe:8kg9, PDBj:8kg9
PDBsum8kg9
PubMed37730685
UniProtP24279|MCM3_YEAST DNA replication licensing factor MCM3 (Gene Name=MCM3)

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