Structure of PDB 8aw3 Chain 3 Binding Site BS01

Receptor Information
>8aw3 Chain 3 (length=279) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMEEVVVPEEPPKLVSALATYVQQERLCTMFLSIANKLLPLKPHACHLKR
IRRSSAVLELLLSVGGPVDSSALKELESAADTTVAVHRVWVPDRAPRSSA
EEWTKWCQIWPFATPKPRVPTQLSECEVGSIQRIFRTVVMPLAKRLRTDE
TLGIAAVLVDPSDGYRVLVSSGEEHALKRGNSAACLGYVSNSGCRKSNRV
VLDHPVTFVLKEVTRYLANGMDMFVSHEPCVMCSMALVHSRVRRVFYCFP
NPVHGGLGSTVSIHAIQELNHHFRVFRCD
Ligand information
>8aw3 Chain 1 (length=73) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggccgcuuagcacaguggcagugcaccacucucguaaagugggggucgcg
aguucgauucucgcaguggccuc
<<<<<<<..<<<<.......>>>>.<<<<<.......>>>.>>....<<<
<<.......>>>>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB8aw3 Structural basis for sequence-independent substrate selection by eukaryotic wobble base tRNA deaminase ADAT2/3
Resolution3.6 Å
Binding residue
(original residue number in PDB)		E24 R166 Y277 N331
Binding residue
(residue number reindexed from 1)		E25 R118 Y216 N270
Enzymatic activity
Enzyme Commision number 3.5.4.33: tRNA(adenine(34)) deaminase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008251 tRNA-specific adenosine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0052717 tRNA-specific adenosine-34 deaminase activity
Biological Process
GO:0002100 tRNA wobble adenosine to inosine editing
GO:0008033 tRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:8aw3, PDBe:8aw3, PDBj:8aw3
PDBsum8aw3
PubMed36347890
UniProtQ381Q7

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