Structure of PDB 7plo Chain 3 Binding Site BS01

Receptor Information
>7plo Chain 3 (length=628) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNV
NDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVG
LEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPAT
KKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITI
QEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGY
TSGTFRTVLIACNVKQMSKDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGH
DYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLC
TAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDE
FDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYD
QYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAP
GEQDGDAMPLGSAVDILATDDPNLHGTKKKKEKMVSAAFMKKYIHVAKII
KPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAH
AKARMSKTVDLQDAEEAVELVQYAYFKK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7plo A conserved mechanism for regulating replisome disassembly in eukaryotes.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		S374 V376 A381 V382 R391 K435
Binding residue
(residue number reindexed from 1)		S364 V366 A371 V372 R381 K425
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005658 alpha DNA polymerase:primase complex
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0016020 membrane
GO:0042555 MCM complex
GO:0048471 perinuclear region of cytoplasm
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7plo, PDBe:7plo, PDBj:7plo
PDBsum7plo
PubMed34700328
UniProtP25205|MCM3_HUMAN DNA replication licensing factor MCM3 (Gene Name=MCM3)

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