Structure of PDB 7pfo Chain 3 Binding Site BS01

Receptor Information
>7pfo Chain 3 (length=620) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNE
KRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSK
HVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRY
SDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAP
AGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGTFRTV
LIACNVKQMSKDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAIL
CLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPT
TGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMD
RTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMEN
IGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAM
PLGSAVDILATDDPNLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQES
ATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKT
VDLQDAEEAVELVQYAYFKK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7pfo Structure of a human replisome shows the organisation and interactions of a DNA replication machine.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		S374 V376 V382 R391 K435
Binding residue
(residue number reindexed from 1)		S356 V358 V364 R373 K417
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005658 alpha DNA polymerase:primase complex
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0016020 membrane
GO:0042555 MCM complex
GO:0048471 perinuclear region of cytoplasm
GO:0071162 CMG complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pfo, PDBe:7pfo, PDBj:7pfo
PDBsum7pfo
PubMed34694004
UniProtP25205|MCM3_HUMAN DNA replication licensing factor MCM3 (Gene Name=MCM3)

[Back to BioLiP]