Structure of PDB 6xtx Chain 3 Binding Site BS01

Receptor Information
>6xtx Chain 3 (length=608) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLPRSPPLPRGNLWELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYR
LIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYE
EFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVH
YCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDH
QTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPG
KKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIF
DQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGD
PSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAG
AMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARC
SVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDRE
ISDHVLRMHRYVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQD
SMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQY
AYFKKVLE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6xtx CryoEM structures of human CMG-ATP gamma S-DNA and CMG-AND-1 complexes.
Resolution3.29 Å
Binding residue
(original residue number in PDB)		S419 V421 V427 K480 A481
Binding residue
(residue number reindexed from 1)		S378 V380 V386 K439 A440
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005658 alpha DNA polymerase:primase complex
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0016020 membrane
GO:0042555 MCM complex
GO:0048471 perinuclear region of cytoplasm
GO:0071162 CMG complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6xtx, PDBe:6xtx, PDBj:6xtx
PDBsum6xtx
PubMed32453425
UniProtP25205|MCM3_HUMAN DNA replication licensing factor MCM3 (Gene Name=MCM3)

[Back to BioLiP]