Structure of PDB 6vbv Chain 3 Binding Site BS01

Receptor Information
>6vbv Chain 3 (length=167) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVHVLCLGLDNSGKTTIINKLKPSNAQSQDIVPTIGFSIQKFKSSSLSFT
VFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDKLRMVVAKEELRTLLNHP
DIKHRRIPILFFANKMDLRDALTSVKVSQLLCLEDIKDKPWHICASDAIK
GEGLQEGVDWLQDQIQS
Ligand information
Ligand IDGTP
InChIInChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyXKMLYUALXHKNFT-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
FormulaC10 H16 N5 O14 P3
NameGUANOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL1233147
DrugBankDB04137
ZINCZINC000060094177
PDB chain6vbv Chain 3 Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6vbv Structure and activation mechanism of the BBSome membrane protein trafficking complex.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		D26 N27 S28 G29 K30 T31 T32 N130 K131 D133 D163 A164
Binding residue
(residue number reindexed from 1)		D10 N11 S12 G13 K14 T15 T16 N114 K115 D117 D147 A148
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005543 phospholipid binding
GO:0062063 BBSome binding
Biological Process
GO:0006612 protein targeting to membrane
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0030030 cell projection organization
GO:0051258 protein polymerization
GO:0060271 cilium assembly
GO:0061512 protein localization to cilium
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005879 axonemal microtubule
GO:0005886 plasma membrane
GO:0005930 axoneme
GO:0030117 membrane coat
GO:0042995 cell projection
GO:0060170 ciliary membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vbv, PDBe:6vbv, PDBj:6vbv
PDBsum6vbv
PubMed31939736
UniProtQ0IIM2|ARL6_BOVIN ADP-ribosylation factor-like protein 6 (Gene Name=ARL6)

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