Structure of PDB 6rax Chain 3 Binding Site BS01

Receptor Information
>6rax Chain 3 (length=625) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EGEQFIKDIQREYVDFLDDEEDQGIYAGHVKDMIAEKSKRLIVNVNDLKR
KNPQRALGLLSNAADEQLAFGRALKEYASTVDPGYAKMHEDLFVGFEGCF
GNRHVTPRSLTSIYLGNMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVME
RKYTDLTSFEAVPSGAAYPTKDEDGNLLETEYGLSVYKDHQTLTIQEMPE
KAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCLPGKRGSGTFRTV
LLANNISLLSKESNLDISREDIMLCKKLAKNNDIFELLSKSLAPSIGHVK
QAILCLLLGGVEKILPNGTRLRGDINVLLGDPSAKSQLLRYVLNTAPRAI
PTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSD
IDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPM
ENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADSL
SFVSSSEEKKDTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAKCMK
PKLGEQACEAIANEYSRLRSQEAVETDVARTQPITARTLETLIRLSTAHA
RARMSKSVTIDDAHAAIELVQFAYF
Ligand information
Receptor-Ligand Complex Structure
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PDB6rax Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.
Resolution3.99 Å
Binding residue
(original residue number in PDB)		S368 S369 A375 V377 T379 R386
Binding residue
(residue number reindexed from 1)		S357 S358 A364 V366 T368 R375
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0032508 DNA duplex unwinding
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rax, PDBe:6rax, PDBj:6rax
PDBsum6rax
PubMed31484077
UniProtQ9XYU1|MCM3_DROME DNA replication licensing factor Mcm3 (Gene Name=Mcm3)

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