Structure of PDB 6i9r Chain 3 Binding Site BS01

Receptor Information
>6i9r Chain 3 (length=95) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKAGYKKKLWKKTPARKKR
LREFVFCNKTQSKLLDKMTTSFWKRRNWYVDDPYQKYHDRTNLKV
Ligand information
>6i9r Chain A (length=1501) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagcc
aaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgc
aauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaa
uauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaa
uaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcua
ccuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggga
agauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguu
guccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccuaa
auccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggac
acuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguag
gccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaa
ucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucac
ccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccucc
gcauaagccugcgucagauaacacaacugacaauuaacagcccaauaucu
acaaucaaccaacaagucauuauuacccucacugucaacccaacacaggc
augcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuua
ccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagagg
caccgccugcccagugacacauguuuaacggccgcgguacccuaaccgug
caaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggc
uccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugc
ccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcu
uuaauuuauuaaugcaaacaguaaccaaaccugcauuaaaaauuucgguu
ggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacu
ucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaac
aaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaac
aauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagc
cgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugag
uucagaccggaguaauccaggucgguuucuaucuacuuauuccucccugu
acgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccgu
aaaugauaucaucucaacuuaguauacccacacccacccaagaacagggu
u
<<.......<<<<.....................................
<......>.........<.....<<.....>>....>........>>.>>
.............<<....>>......................>>.....
.......<<<.......>>>...<.<........>.>.<<<<<<......
...<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<
<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>.
...>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..
<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<.......
.>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>
...<<<......>>>....<<<.<<<...<..............<....<
<<.........>>>....>.......<<<......>>>............
...............>...>>>>>>........>>>>>>...<<<<<...
...>>>>>.........>>>>>><......<<..<<<....>>><<<<..
<<<<........<<<<<.........>>>>>......<<<...<<<<...
....................>>>>.......>>>.....<<......>>.
>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<
<<<<<..<<<.........>>>...<<<<<<.............>>>>>>
....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>
........<...........<<<<<<.....>>>>>>.....>....>>>
....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<
<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<
..<<<<..<<<<<<<<...............>>>>>>>>.>>>>..<<<<
.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<
.....>>>>..>>>....>>.........<<<....>>>...........
.>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...
>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<.....
.>>>>>>...>>.<<<<.......>>>>.....>>>>>..>...>>>.>>
....<<<<<<<....>>>.>>>>....>>..>>>.>>.<<<.<<<.....
............>>>.>>><<<<<...<<<....>>>.>>>>>......<
<<................>>>..............<<<<.......>>>>
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6i9r Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		L94 T95 Y96 F97 S98 A99 R100 K101 K103 R104 K105 T106 V107 K108 R113 H118 R124 K126 A127 G128 K131 K132 L133 W134 K135 R140 K142 R143 K156 K160 F165 W166 R168 R169 D182
Binding residue
(residue number reindexed from 1)		L1 T2 Y3 F4 S5 A6 R7 K8 K10 R11 K12 T13 V14 K15 R20 H25 R31 K33 A34 G35 K38 K39 L40 W41 K42 R47 K49 R50 K63 K67 F72 W73 R75 R76 D89
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005761 mitochondrial ribosome
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6i9r, PDBe:6i9r, PDBj:6i9r
PDBsum6i9r
PubMed33910005
UniProtQ9NZE8|RM35_HUMAN Large ribosomal subunit protein bL35m (Gene Name=MRPL35)

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