Structure of PDB 4ce4 Chain 3 Binding Site BS01

Receptor Information

>4ce4 Chain 3 (length=59) Species: 9825 (Sus scrofa domesticus)

KLHIVTRIKSTKRRPYWEKDIIKMLGLEKAHTPQVHKNIPSVNAKLKVVK
HLIRIKPLK

Ligand information

>4ce4 Chain A (length=1444)

accaaagcuagcucaacauuuuuuuuaaauaaaauaaaacauucaccuaa
cauuaaaguauaggagauagaaauuuuuauccugacgcuauagagauagu
accguaagggaaagaugaaagaauaaaauaaaaguaaaaaaaagcaaaga
uuaccccuucuaccuuuugcauaaugguuuaaccagaaaaaaucuaacaa
agagaacuuuagcuagauaccccgaaaccagacgagcuacccaugagcag
uuuaaaagaaccaacucaucuauguggcaaaauagugagaagacuuguag
guagaggugaaaagccuaacgagccuggugauagcugguuguccgagaaa
gaauuuuaguucaaccuuaaaaauaccccaaaaauuccaauguauuuuua
agagauagucuaaaaagguacagcuuuuuagaaacggauacaaccuugac
uagagaguaaaucuuaauacacauaaucccaaaaaaacaaacuccuagcc
caauaccggacuaaucuauugaaacauagaagcaauaauguuaauaugag
uaacaagaagccuuucuccucgcacacgcuuacaucaguaacuaauaaua
uacugauaauuaacaaccaauaaaccaaaacaacacuaaaacguuuauua
auuacauuguuaacccaacacaggagugcaccaaggaaagauuaaaagaa
guaaaaggaacucggcaaacacaaaccccgccuguuuaccaaaaacauca
ccucuagcauuacuaguauuagaggcaaugccugcccagugacaccaguu
uaacggccgcgguauucugaccgugcaaagguagcauaaucacuuguucu
ccaaauaaggacuuguaugaauggccacacgaggguuuuacugucucuua
cuuccaaucagugaaauuaaccuucccgugaagaggcgggaauaaaaaaa
uaagacgagaagacccuauggagcuuuaauuaacuauuccaaaaguuaaa
cuuaacauggacuagcaauuucgguuggggugaccucggaguacaaaaaa
cccuccgagugauuuuaaucuagacaaaccagucaaaauaacccaucacu
uauugauccaaaauuuugaucaacggaacaaguuacccuagggauaacag
cgcaauccuguucuagaguuccuaucgacaauaggguuuacgaccucgau
guuggaucaggacacccaaauggugcagccgcuauuaaagguucguuugu
ucaacgauuaaaguccuacgugaucugaguucagaccggagcaauccagg
ucgguuucuaucuauuauaaauuucucccaguacgaaaggacaagagaaa
ugggaccaaccucacaaacgcgucucagagauaauuaaugauuuaaucuu
aaccuaauuaacucauaauaaauccagcccuagaacagggcaca

.........<<<<<.....................<......>.......
..........<<.....>>..............>>.>>>...........
.<<....>>.....................................<<<.
......>>>...<............>..<<<<<........<<<<<.<..
<<....>>...>.>>>>>..<<.<...<<<<.<.....<<<.<<<<<..<
<<<....>>>>...<<<..<<<<........>>>>.>>>....>>>>>.>
>>...<<<.....>>>......>.>>>>......>.>>..<<<<<.....
<<<<....>>>>..<<<<<<<<<<<<.....<<.>>.....>>>>>>>>>
>>.>....<<<<<<<<<......>>>>>>>>>...<<......>>....<
<<<.<<<..................................>>>>>>>..
......>>>>>...<<<<<......>>>>>.........>>>>>.<....
..<<..<<<<..>>>><<<..<<<<........<<<<<....<<....>>
..>>>>>......<<<..<<<<<<<.................>>>>>>>.
......>>>.....<<......>>.>>>>.....>>>..<<<<....<<<
<<<<.<<...............<<<<<<<<..<<<.........>>>...
<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>
..>>>>><<<<<<......>>>>>>........<...........<<<<<
.......>>>>>.....>....>>>....>>.>>>>>>......>>.>>>
>>>>.>>>>.>>.....>.....<<<<<........>>>>>.......<<
<.<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<.<<<<...>
>>>....>>>>.>>>.>>>>..<<<<.....>>>><<<<<<.........
..>>>>>>.<<<<....<<.<.<<<......>>>.>.>>.....>>>>..
........<<<....>>>............>>>>..>>>>>>.......<
<<....<<<<<<...<<.......>>...>>>>>>.....>>.>......
.<.<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<...
..>>>>>.....>>>>>..>...>>>..>....<<<.<<<....>>>..>
>>....>>..>>>>>>.<<.<<<<<<<.................>>>>>>
><<<<<...............>>>>>.<<<.....<..............
......>....>>>.>>.........<<<<.......>>>>...

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4ce4 Architecture of the Large Subunit of the Mammalian Mitochondrial Ribosome.
• Resolution: 4.9 Å
• Binding residue (original residue number in PDB): R71 K73 S74 K76 R77 Y80 M88 A94 S105
• Binding residue (residue number reindexed from 1): R7 K9 S10 K12 R13 Y16 M24 A30 S41

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4ce4, PDBe:4ce4, PDBj:4ce4
• PDBsum: 4ce4
• PubMed: 24362565
• UniProt: A0A8D1MIP3