Structure of PDB 2hwe Chain 3 Binding Site BS01

Receptor Information
>2hwe Chain 3 (length=238) Species: 12134 (Human rhinovirus 1A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLPVYITPGSGQFMTTDDMQSPCALPWYHPTKEISIPGEVKNLIEMCQVD
TLIPVNNVGNNVGNVSMYTVQLGNQTGMAQKVFSIKVDITSTPLATTLIG
EIASYYTHWTGSLRFSFMFCGTANTTLKLLLAYTPPGIDEPTTRKDAMLG
THVVWDVGLQSTISLVVPWVSASHFRLTADNKYSMAGYITCWYQTNLVVP
PSTPQTADMLCFVSACKDFCLRMARDTDLHIQSGPIEQ
Ligand information
>2hwe Chain 4 (length=19) Species: 12134 (Human rhinovirus 1A) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
YFNINYFKDAASSGASRLD
Receptor-Ligand Complex Structure
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PDB2hwe A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		D18 Q20 S21 C23 P26 W27
Binding residue
(residue number reindexed from 1)		D18 Q20 S21 C23 P26 W27
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0005198 structural molecule activity

View graph for
Molecular Function
External links
PDB RCSB:2hwe, PDBe:2hwe, PDBj:2hwe
PDBsum2hwe
PubMed8383771
UniProtP23008|POLG_HRV1A Genome polyprotein

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