Structure of PDB 5hcr Chain 2t Binding Site BS01

Receptor Information
>5hcr Chain 2t (length=96) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RNLSALKRHRQSLKRRLRNKAKKSAIKTLSKKAIQLAQEGKAEEALKIMR
KAESLIDKAAKGSTLHKNAAARRKSRLMRKVRQLLEAAGAPLIGGG
Ligand information
>5hcr Chain 2a (length=1483) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaaga
caugcaagucgugcgggccgcgggguacuccguggucagcggcggacggg
ugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaa
cucgggcuaaucccccauguggacccgccccuugggguguguccaaaggg
cuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggggu
aauggcccaccaaggcgacgacggguagccggucugagaggauggccggc
cacaggggcacugagacacgggccccacuccuacgggaggcagcaguuag
gaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggagga
agaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacg
aggggacugacgguaccgggguaauagcgccggccaacuccgugccagca
gccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaa
agggcguguaggcggccuggggcgucccaugugaaagaccacggcucaac
cgugggggagcgugggauacgcucaggcuagacggugggagaggguggug
gaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgau
ggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcgug
gggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcg
cgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgc
cgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggggg
cccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaac
cuuaccaggccuugacaugcuagggaacccgggugaaagccugggccuag
cacaggugcugcauggccgucgucagcucgugccgugagguguuggguua
agucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccg
ggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacg
ucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcc
cacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggug
ggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucg
cuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuug
uacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgg
gagccuacgggcaggcgccgaggguagggcccgugacuggggcggucgua
acaagguagcuguaccggaaggugcggcuggau
.....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<
<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<
<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<.....
.>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<
<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<..
.....>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>
.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>.
.......<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<..
....<<<<....>>>>.....>>>>....<<<<<......<.<<<<....
.>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.
)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((..
...<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>
>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.
...<<<<<<<.<..<<<......>>>.....>.>>>>>>>..........
.<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<
<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<
<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>
.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<
<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>......
....<<<<<<<......<<<<<<....<<<<<<<....>>>>>>>.>>>>
>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<...
...>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>
>>>...>>>>>>>.....<<<<<....>>>>>........>>>>......
...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<
<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>
>>>......<....<<<<<<<........>>>>>>>....>.....>>>>
>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>
>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<..
..<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>..
.......<<<<<<<<<....>>>>>>>>>....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5hcr Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		A12 K14 R15 H16 R17 S19 R22 N26 A28 K29 S31 A32 K34 T35 K38 K39 E51 K54 E60 S61 D64 K65 K68 S70 H73 N75 A78 R79 K81 S82 R83 M85 R89 G101 G102 G103
Binding residue
(residue number reindexed from 1)		A5 K7 R8 H9 R10 S12 R15 N19 A21 K22 S24 A25 K27 T28 K31 K32 E44 K47 E53 S54 D57 K58 K61 S63 H66 N68 A71 R72 K74 S75 R76 M78 R82 G94 G95 G96
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0070181 small ribosomal subunit rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5hcr, PDBe:5hcr, PDBj:5hcr
PDBsum5hcr
PubMed26809677
UniProtP80380|RS20_THET8 Small ribosomal subunit protein bS20 (Gene Name=rpsT)

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