Structure of PDB 5hcr Chain 2l Binding Site BS01

Receptor Information
>5hcr Chain 2l (length=122) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRK
VAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGV
YDAAGVKDRKKSRSKYGTKKPK
Ligand information
>5hcr Chain 2a (length=1483) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaaga
caugcaagucgugcgggccgcgggguacuccguggucagcggcggacggg
ugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaa
cucgggcuaaucccccauguggacccgccccuugggguguguccaaaggg
cuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggggu
aauggcccaccaaggcgacgacggguagccggucugagaggauggccggc
cacaggggcacugagacacgggccccacuccuacgggaggcagcaguuag
gaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggagga
agaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacg
aggggacugacgguaccgggguaauagcgccggccaacuccgugccagca
gccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaa
agggcguguaggcggccuggggcgucccaugugaaagaccacggcucaac
cgugggggagcgugggauacgcucaggcuagacggugggagaggguggug
gaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgau
ggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcgug
gggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcg
cgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgc
cgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggggg
cccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaac
cuuaccaggccuugacaugcuagggaacccgggugaaagccugggccuag
cacaggugcugcauggccgucgucagcucgugccgugagguguuggguua
agucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccg
ggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacg
ucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcc
cacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggug
ggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucg
cuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuug
uacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgg
gagccuacgggcaggcgccgaggguagggcccgugacuggggcggucgua
acaagguagcuguaccggaaggugcggcuggau
.....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<
<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<
<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<.....
.>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<
<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<..
.....>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>
.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>.
.......<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<..
....<<<<....>>>>.....>>>>....<<<<<......<.<<<<....
.>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.
)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((..
...<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>
>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.
...<<<<<<<.<..<<<......>>>.....>.>>>>>>>..........
.<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<
<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<
<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>
.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<
<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>......
....<<<<<<<......<<<<<<....<<<<<<<....>>>>>>>.>>>>
>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<...
...>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>
>>>...>>>>>>>.....<<<<<....>>>>>........>>>>......
...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<
<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>
>>>......<....<<<<<<<........>>>>>>>....>.....>>>>
>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>
>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<..
..<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>..
.......<<<<<<<<<....>>>>>>>>>....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5hcr Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		P5 N8 Q9 R12 R15 E16 A30 P31 F32 R33 R34 N49 S50 L52 R53 K54 T61 Y69 G72 E73 R86 G87 K91 D92 R97 V104 R113 K114 K115 S116 R117 S118 K119 T122 K123 K124
Binding residue
(residue number reindexed from 1)		P1 N4 Q5 R8 R11 E12 A26 P27 F28 R29 R30 N45 S46 L48 R49 K50 T57 Y65 G68 E69 R82 G83 K87 D88 R93 V100 R109 K110 K111 S112 R113 S114 K115 T118 K119 K120
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5hcr, PDBe:5hcr, PDBj:5hcr
PDBsum5hcr
PubMed26809677
UniProtQ5SHN3|RS12_THET8 Small ribosomal subunit protein uS12 (Gene Name=rpsL)

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