Structure of PDB 7u2h Chain 2f Binding Site BS01

Receptor Information
>7u2h Chain 2f (length=100) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRRYEVNIVLNPNLDQSQLALEKEIIQRALENYGARVEKVEELGLRRLAY
PIAKDPQGYFLWYQVEMPEDRVNDLARELRIRDNVRRVMVVKSQEPFLAN
Ligand information
>7u2h Chain 2a (length=1503) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaaga
caugcaagucgugcgggccgcgggguacuccguggucagcggcggacggg
ugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaa
cucgggcuaaucccccauguggacccgccccuugggguguguccaaaggg
cuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggggu
aauggcccaccaaggcgacgacggguagccggucugagaggauggccggc
cacaggggcacugagacacgggccccacuccuacgggaggcagcaguuag
gaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggagga
agaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacg
aggggacugacgguaccgggguaauagcgccggccaacuccgugccagca
gccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaa
agggcguguaggcggccuggggcgucccaugugaaagaccacggcucaac
cgugggggagcgugggauacgcucaggcuagacggugggagaggguggug
gaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgau
ggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcgug
gggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcg
cgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgc
cgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggggg
cccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaac
cuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugcc
ccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgug
ccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuag
uugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcggg
aggaaggaggggacgacgucuggucagcauggcccuuacggccugggcga
cacacgugcuacaaugcccacuacaaagcgaugccacccggcaacgggga
gcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgac
cccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcgguga
auacguucccgggccuuguacacaccgcccgucacgccaugggagcgggc
ucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggccc
gugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcug
gau
.....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<
<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<
<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<.....
.>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<
<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<..
.....>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>
.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>.
.......<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<..
....<<<<....>>>>.....>>>>....<<<<<........<<<<....
.>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.
)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((..
...<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>
>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.
...<<<<<<<.<..<<<......>>>.....>.>>>>>>>..........
.<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<
<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<
<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>
.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<
<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>......
....<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<
<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<
<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<
..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>
........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>
>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..
>>....>>>.....>>>>>>>......<....<<<<<<<........>>>
>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>..
....>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<
<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>
>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.
...
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7u2h Structural basis for the inability of chloramphenicol to inhibit peptide bond formation in the presence of A-site glycine.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		R2 Y4 E69 V72 N73 R77 R80 R87 V90 V91 K92
Binding residue
(residue number reindexed from 1)		R2 Y4 E69 V72 N73 R77 R80 R87 V90 V91 K92
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0070181 small ribosomal subunit rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7u2h, PDBe:7u2h, PDBj:7u2h
PDBsum7u2h
PubMed35766409
UniProtQ5SLP8|RS6_THET8 Small ribosomal subunit protein bS6 (Gene Name=rpsF)

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