Structure of PDB 4z8c Chain 2c Binding Site BS01

Receptor Information
>4z8c Chain 2c (length=206) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GNKIHPIGFRLGITRDWESRWYAGKKQYRHLLLEDQRIRGLLEKELYSAG
LARVDIERAADNVAVTVHVAKPGVVIGRGGERIRVLREELAKLTGKNVAL
NVQEVQNPNLSAPLVAQRVAEQIERRFAVRRAIKQAVQRVMESGAKGAKV
IVSGRIGGAEQARTEWAAQGRVPLHTLRANIDYGFALARTTYGVLGVKAY
IFLGEV
Ligand information
>4z8c Chain 2a (length=1483) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaaga
caugcaagucgugcgggccgcgggguacuccguggucagcggcggacggg
ugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaa
cucgggcuaaucccccauguggacccgccccuugggguguguccaaaggg
cuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggggu
aauggcccaccaaggcgacgacggguagccggucugagaggauggccggc
cacaggggcacugagacacgggccccacuccuacgggaggcagcaguuag
gaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggagga
agaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacg
aggggacugacgguaccgggguaauagcgccggccaacuccgugccagca
gccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaa
agggcguguaggcggccuggggcgucccaugugaaagaccacggcucaac
cgugggggagcgugggauacgcucaggcuagacggugggagaggguggug
gaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgau
ggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcgug
gggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcg
cgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgc
cgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggggg
cccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaac
cuuaccaggccuugacaugcuagggaacccgggugaaagccugggccuag
cacaggugcugcauggccgucgucagcucgugccgugagguguuggguua
agucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccg
ggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacg
ucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcc
cacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggug
ggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucg
cuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuug
uacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgg
gagccuacgggcaggcgccgaggguagggcccgugacuggggcggucgua
acaagguagcuguaccggaaggugcggcuggau
.....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<
<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<
<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<.....
.>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<
<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<..
.....>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>
.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>.
.......<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<..
....<<<<....>>>>.....>>>>....<<<<<......<.<<<<....
.>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.
)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((..
...<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>
>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.
...<<<<<<<.<..<<<......>>>.....>.>>>>>>>..........
.<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<
<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<
<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>
.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<
<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>......
....<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>>>>>>
>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<...
...>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>
>>>...>>>>>>>.....<<<<<....>>>>>........>>>>......
...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<
<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>
>>>......<....<<<<<<<........>>>>>>>....>.....>>>>
>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>
>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<..
..<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>..
.>.....<<<<<<<<<....>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB4z8c The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		G2 N3 K4 I5 S154 G155 R156 E161 A163 R172 V173 P174 H176 T177 L178 R179 T192 Y193 G194 V195 L196
Binding residue
(residue number reindexed from 1)		G1 N2 K3 I4 S153 G154 R155 E160 A162 R171 V172 P173 H175 T176 L177 R178 T191 Y192 G193 V194 L195
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4z8c, PDBe:4z8c, PDBj:4z8c
PDBsum4z8c
PubMed25984972
UniProtP80372|RS3_THET8 Small ribosomal subunit protein uS3 (Gene Name=rpsC)

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