Structure of PDB 8vty Chain 2R Binding Site BS01 |
|
>8vty Chain 2A (length=2867)
[Search RNA sequence]
[Download ligand structure]
[Download structure with residue number starting from 1]
[View ligand structure]
|
agaugguaagggcccacgguggaugccucggcacccgagccgaugaagga cguggcuaccugcgauaagccagggggagccgguagcgggcguggauccc uggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgc ugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagag gaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccu aaaccguccggcuuguccgggcggggucguggggcccucggacaccgaau ccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagc cccguaggcgaaagguggggggauaggugaggguacccgaguaccccgug guucguggagccaugggggaaucugggcggaccaccgccuaaggcuaagu acuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaaga accccgggaggggagugaaauagagccugaaaccgugggcuuacaagcag ucacggccccggggguuguggcgugccuauugaagcaugagccggcgacu cacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccg aguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaac cgggcgagcuagcccuggccagggugaagcuggggugagacccaguggag gcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggag ugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuu agggucagccucaggcgcugacuggggccuguagagcacugauagggcua gggggcccaccagccuaccaaacccugucaaacuccgaagggucccaggu ggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcggg aacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaa ggauguggcgccgcgaagacagccaggagguggcuuagaagcagccaucc uuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaau gaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcg guaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcug gagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugag aaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcgu aggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcag ccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuag gcuagggggaccggagccauggacgagcccggccagaagcgcaggguggg agguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgc gggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaa ccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagc acucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggcccc guaacuucgggagaaggggugcucccuggggugaugagccccggggagcc gcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcga acucguaagaggagguauagggagcgacgcuugcccggugccggaagguc aaggggaggggugcaagccccgaaccgaagccccggugaacggcggccgu aacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgac cugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggu gaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaag accccguggagcuuuacugcagccugguguuggcucuuggucgcgccugc guaggauaggugggagccugugaacccccgccuccgggugggggggaggc gccggugaaauaccacccuggcgcggcugggggccuaacccucggauggg gggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagg uaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggag agcgcaaggguagaagggggccugacugcgaggccugcaagccgagcagg ggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucg aucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagc guccacagcggcggggagguuuggcaccucgaugucggcucgucgcaucc uggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggc acgcgagcuggguucagaacgucgugagacaguucggucucuauccgcca cgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaa gggacgcaccucugguuucccagcugucccuccaggggcauaagcugggu agccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccg ccccaagaugaggccucccggcagccgguaaggacccgggaagaccaccc gguggaugggccggggguguaagcgccgcgaggcguugagccgaccgguc ccaaucguccgaggucu |
<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<< <<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>> >>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<< .>>>>>>.>>...<<<<<<.....<......>......>>>>>.>..... ....<<....>>...<<<<<.....<<.....>>....>>>>>...<<<. ...<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...< <<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....)) >>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<< <<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>..... .>>.>>>>>>.>>...............<<....>>....>>........ .<<<<....>>>>..................>>>>>>>>>>>.......< <<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<.... <<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>. .<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...< <<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.... .>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<< <.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<.. ..>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<... <<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.. ...>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<. .....>>>...<<<<.<<<...<<<(((.....<<<<<<........... <<..<<<<<<<<<........<<<<<.<<...<<<.......>>>....> >......................>>>>>....>>>>>>>>>.>>...... ....)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>. ...>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>. ..>>>..>>>>>........>>>>>><......<<.....<<<<<<.... ...>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>> >>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...< <<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.< <<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<< <<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<.. >>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...> >>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>> >>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<< .....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>. ...........<<<<<<<<<..<<<.........>>>..<<<<<<<.... .<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<. ..<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<< .......>>>>>>........<...........<<<<<<.....>>>>>> .....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>> .....>.....<<<<<........>>>>>..<<<<<<<<.<<<....... ..<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<... ........<<<<<..<<<.......<<<<<<......>>>>>>....>>> ............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>> >>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<....... ....>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.... .<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>. <<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>> .............>>>>..>>>>>>.......<<<<.<.<<<<<<...<< .......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<< <<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>> ..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>> >>>>....<<<<<<<...<<<<..<<<<<<<...............>>>> >>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>.. .>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>. >>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>> >>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>. >>>...>>>>....>>> |
|
Global view | Local view | Structure summary |
[Spin on]
[Spin off]
[Reset]
[High quality]
[Low quality]
[White background]
[Black background]
|
[Spin on]
[Spin off]
[Reset]
[High quality]
[Low quality]
[White background]
[Black background]
|
PDB | 8vty Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms. |
Resolution | 2.6 Å |
Binding residue (original residue number in PDB) | M1 R2 H3 L4 K5 S6 R8 K9 L10 N11 R12 H13 S14 S15 H16 R17 L20 R22 N23 Q24 K26 S27 H31 I34 T35 T36 T37 P39 K40 K42 R45 D49 H50 H53 L60 H61 R63 R64 L67 R68 Q71 R77 R90 Q91 G92 G93 R96 K99 R104 R105 G106 D107 |
Binding residue (residue number reindexed from 1) | M1 R2 H3 L4 K5 S6 R8 K9 L10 N11 R12 H13 S14 S15 H16 R17 L20 R22 N23 Q24 K26 S27 H31 I34 T35 T36 T37 P39 K40 K42 R45 D49 H50 H53 L60 H61 R63 R64 L67 R68 Q71 R77 R90 Q91 G92 G93 R96 K99 R104 R105 G106 D107 |
|
|
|