Structure of PDB 8vtv Chain 2R Binding Site BS01 |
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>8vtv Chain 2A (length=2800)
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agaugguaagggcccacgguggaugccucggcacccgagccgaugaagga cguggcuaccugcgauaagccagggggagccgguagcgggcguggauccc uggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgc ugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagag gaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccu aaaccguccggcuuguccgggcggggucguggggcccucggacaccgaau ccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagc cccguaggcgaaagguggggggauaggugaggguacccgaguaccccgug guucguggagccaugggggaaucugggcggaccaccgccuaaggcuaagu acuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaaga accccgggaggggagugaaauagagccugaaaccgugggcuuacaagcag ucacggccccggggguuguggcgugccuauugaagcaugagccggcgacu cacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccg aguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaac cgggcgagcuagcccuggccagggugaagcuggggugagacccaguggag gcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggag ugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuu agggucagccucaggcgcugacuggggccuguagagcacugauagggcua gggggcccaccagccuaccaaacccugucaaacuccgaagggucccaggu ggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcggg aacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaa ggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagccc agcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccg augccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcg aaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaa gcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccu aaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggc ccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagc cauggacgagcccggccagaagcgcagggugggagguaggcaaauccgcc ucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccga agccagggagccaagaaaagccucuaagcacaaccugcgggaacccguac cgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggag aacccucgccaaggaacucugcaaguuggccccguaacuucgggagaagg ggugcucccuggggugaugagccccggggagccgcagugaacaggcucug gcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggaggua uagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaag ccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaa gguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaa cgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgu gaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuac ugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagc cugugaacccccgccuccgggugggggggaggcgccggugaaauaccacc cuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgg gcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaa gguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagg gggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccua gugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguu accccggggauaacaggcugaucucccccgagcguccacagcggcgggga gguuuggcaccucgaugucggcucgucgcauccuggggcugaagaagguc ccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucag aacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuug aggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguu ucccagcugucccuccaggggcauaagcuggguagccaugugcggaaggg auaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccuc ccggcagccgguaaggacccgggaagaccacccgguggaugggccggggg uguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu |
<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<< <<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>> >>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<< .>>>>>>.>>...<<<<<<.....<......>......>>>>>.>..... ....<<....>>...<<<<<.....<<.....>>....>>>>>...<<<. ...<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...< <<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....)) >>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<< <<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>..... .>>.>>>>>>.>>...............<<....>>....>>........ .<<<<....>>>>..................>>>>>>>>>>>.......< <<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<.... <<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>. .<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<..<< <<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.... .>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<< <.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<.. ..>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<... .<<............>.>....>>>>>>>>..>>.>...>>>>>>>>>.. ...>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<. .....>>>...<<<<.<<<...<<<(((.....<<<<<<........... <<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>> >>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<. ..<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.. ...>>>>>><......<<.....<<<<<<.......>>>>>><<<<.... <<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<. ..<<<...<<<....>>>...>>>...>>...<<<<<........>>>>> ))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<< ..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>> >>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>.. .>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..> >.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<.. ..<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>> >>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<< <<<..<<<.........>>>..<<<<<<<.....<<<....>>>...... .>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....> >>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>.... ....<...........<<<<<<.....>>>>>>.....>....>>>>>.. >>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<. .......>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<< <<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<< <......<<<<<<<<....>>>>>>>>...>>>............>>>>> ..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>.. >>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<... <<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>> >>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))). ......<<<<<<<.<<..))))..>>>>>>>>>.............>>>> ..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>> >...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>> >>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....< <<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<.. .<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<. ..<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<< ....<<<<<...........>>>>>....>>>.>>>>.......>>>>>> >.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<< <....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> |
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PDB | 8vtv Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms. |
Resolution | 2.55 Å |
Binding residue (original residue number in PDB) | M1 R2 H3 L4 K5 S6 R8 K9 L10 N11 R12 H13 S14 S15 H16 R17 R22 N23 Q24 K26 H31 I34 T35 T36 T37 P39 K40 K42 R45 G46 D49 H50 H53 R57 L60 H61 R63 R64 L67 R68 R77 R90 Q91 G92 G93 R96 K99 R105 G106 D107 |
Binding residue (residue number reindexed from 1) | M1 R2 H3 L4 K5 S6 R8 K9 L10 N11 R12 H13 S14 S15 H16 R17 R22 N23 Q24 K26 H31 I34 T35 T36 T37 P39 K40 K42 R45 G46 D49 H50 H53 R57 L60 H61 R63 R64 L67 R68 R77 R90 Q91 G92 G93 R96 K99 R105 G106 D107 |
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