Structure of PDB 8uvr Chain 2Q Binding Site BS01 |
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>8uvr Chain 2A (length=2800)
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agaugguaagggcccacgguggaugccucggcacccgagccgaugaagga cguggcuaccugcgauaagccagggggagccgguagcgggcguggauccc uggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgc ugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagag gaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccu aaaccguccggcuuguccgggcggggucguggggcccucggacaccgaau ccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagc cccguaggcgaaagguggggggauaggugaggguacccgaguaccccgug guucguggagccaugggggaaucugggcggaccaccgccuaaggcuaagu acuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaaga accccgggaggggagugaaauagagccugaaaccgugggcuuacaagcag ucacggccccggggguuguggcgugccuauugaagcaugagccggcgacu cacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccg aguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaac cgggcgagcuagcccuggccagggugaagcuggggugagacccaguggag gcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggag ugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuu agggucagccucaggcgcugacuggggccuguagagcacugauagggcua gggggcccaccagccuaccaaacccugucaaacuccgaagggucccaggu ggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcggg aacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaa ggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagccc agcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccg augccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcg aaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaa gcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccu aaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggc ccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagc cauggacgagcccggccagaagcgcagggugggagguaggcaaauccgcc ucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccga agccagggagccaagaaaagccucuaagcacaaccugcgggaacccguac cgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggag aacccucgccaaggaacucugcaaguuggccccguaacuucgggagaagg ggugcucccuggggugaugagccccggggagccgcagugaacaggcucug gcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggaggua uagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaag ccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaa gguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaa cgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgu gaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuac ugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagc cugugaacccccgccuccgggugggggggaggcgccggugaaauaccacc cuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgg gcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaa gguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagg gggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccua gugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguu accccggggauaacaggcugaucucccccgagcguccacagcggcgggga gguuuggcaccucgaugucggcucgucgcauccuggggcugaagaagguc ccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucag aacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuug aggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguu ucccagcugucccuccaggggcauaagcuggguagccaugugcggaaggg auaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccuc ccggcagccgguaaggacccgggaagaccacccgguggaugggccggggg uguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu |
<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<< <<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>> >>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<< .>>>>>>.>>...<<<<<<.....<......>......>>>>>.>..... ....<<....>>...<<<<<.....<<.....>>....>>>>>...<<<. ...<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...< <<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....)) >>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<< <<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>..... .>>.>>>>>>.>>...............<<....>>....>>........ .<<<<....>>>>..................>>>>>>>>>>>..<....< <<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<.... <<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>. .<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...< <<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.... .>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<< <.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<.. ..>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<... <<<............>.>>...>>>>>>>>..>>.>...>>>>>>>>>.. ...>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<. .....>>>...<<<<.<<<...<<<(((.....<<<<<<........... <<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>> >>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<. ..<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..... ...>>>>>><......<<.....<<<<<<.......>>>>>><<<<.... <<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<. ..<<<...<<<....>>>...>>>...>>...<<<<<........>>>>> ))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<< ..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>> >>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>.. .>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..> >.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<.. ..<<<<<<<<.<<.........<.....<<<<<.....<..>......>> >>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<< <<<..<<<.........>>>..<<<<<<<.....<<<....>>>...... .>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....> >>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>.... ....<...........<<<<<<.....>>>>>>.....>....>>>>>.. >>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<. .......>>>>>>.<<<<<<<<.<<<.........<<<<.<<<<<<..<< <<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<< <......<<<<<<<<....>>>>>>>>...>>>............>>>>> ..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>.. >>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<... <<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>> >>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))). ......<<<<<<<.<<..))))..>>>>>>>>>.............>>>> ..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>> >...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>> >>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....< <<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<.. .<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<. ..<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<< ....<<<<<...........>>>>>....>>>.>>>>.......>>>>>> >.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<< <....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> |
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PDB | 8uvr Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus. |
Resolution | 2.6 Å |
Binding residue (original residue number in PDB) | P4 R5 R6 K8 Y9 K11 Q13 R14 R16 L17 K22 G24 Y26 A28 F29 W41 Q45 Q46 A49 R56 K63 R67 F69 D71 Y74 K76 K77 E80 V81 R82 M83 G84 K85 K87 R101 R119 H123 K124 P126 K128 |
Binding residue (residue number reindexed from 1) | P4 R5 R6 K8 Y9 K11 Q13 R14 R16 L17 K22 G24 Y26 A28 F29 W41 Q45 Q46 A49 R56 K63 R67 F69 D71 Y74 K76 K77 E80 V81 R82 M83 G84 K85 K87 R101 R119 H123 K124 P126 K128 |
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