Structure of PDB 8h6l Chain 2G Binding Site BS01

Receptor Information
>8h6l Chain 2G (length=1048) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGYHAPVALLNDIPQSTPFAEHRPPKIADREDEYKKHRRTMIISAEKAKA
GELKVVNGAAASADQTPGATPKKLSSWDQAETPGHTPSLRWDETPGRAKG
SETPGATPGSKIWDPTPSERDTPGHGSGWAETPRTDRGGDSIGETPTERN
RPLSDEELDAMFPEGYKVLPPPAGYVPIRTPARKLTATPTPLGGMTGFHM
QKSVNDQPSGNLPFLKPDDIQYFDKLLVDVDESEEQKERKIMKLLLKIKN
GTPPMRKAALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVI
DRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGL
ATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKK
SWQARHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISA
LAIAALAEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPL
MDAEYANYYTREVMLILIREFQSPDEEMKKIVLKVVKQCCGTDGVEANYI
KTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDD
LKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTE
DSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLIS
RTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGM
HKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWM
RICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQER
QNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFE
YIGEMGKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCED
SLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFH
PARKVRDVYWKIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL
Ligand information
>8h6l Chain A (length=57) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuuccuugaagcuuucgugcugacccugucccuuuuuuuuccuaccaggu
gaguaug
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Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8h6l Structural Insights into Human Exon-defined Spliceosome Prior to Activation
Resolution2.6 Å
Binding residue
(original residue number in PDB)		A514 A515 R1106
Binding residue
(residue number reindexed from 1)		A258 A259 R850
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:1990935 splicing factor binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006338 chromatin remodeling
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0034693 U11/U12 snRNP
GO:0071004 U2-type prespliceosome
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0110016 B-WICH complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h6l, PDBe:8h6l, PDBj:8h6l
PDBsum8h6l
PubMed38658629
UniProtO75533|SF3B1_HUMAN Splicing factor 3B subunit 1 (Gene Name=SF3B1)

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