Structure of PDB 8h6l Chain 2D Binding Site BS01

Receptor Information
>8h6l Chain 2D (length=236) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAFDLDVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFT
KLVEQYTKILIPPKGLFSKLDQVCYRVEWAKFQERERKKEEEEKEKERVA
YAQIDWHDFVVVETVNFPPPTTPELVSPITGEKIPASKMQEHMRIGLLDP
RWLEQRDRSIREKQSDDEVYAPGLDIESSLKQLAERRTDIFGVEETAIGK
KIGEKVTWDGHSGSMARTQQAAQANITLQEQIEAIH
Ligand information
>8h6l Chain 6A (length=59) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acgauacagagaagauuagcauggccccugcgcaaggaugacauucguga
agcguauuu
..................................................
.........
Receptor-Ligand Complex Structure
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PDB8h6l Structural Insights into Human Exon-defined Spliceosome Prior to Activation
Resolution2.6 Å
Binding residue
(original residue number in PDB)		H505 S506 G507
Binding residue
(residue number reindexed from 1)		H211 S212 G213
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000389 mRNA 3'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045292 mRNA cis splicing, via spliceosome
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0016607 nuclear speck
GO:0071004 U2-type prespliceosome
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h6l, PDBe:8h6l, PDBj:8h6l
PDBsum8h6l
PubMed38658629
UniProtQ15459|SF3A1_HUMAN Splicing factor 3A subunit 1 (Gene Name=SF3A1)

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