Structure of PDB 7a01 Chain 22 Binding Site BS01

Receptor Information
>7a01 Chain 22 (length=135) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPR
KVTAAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSVDIPLDKTVVNKDVF
RDPALKRKARREAKVKFEERYKTGKNKWFFQKLRF
Ligand information
>7a01 Chain e2 (length=3825) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacau
guggcguacggaagacccgcuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccggaggauucaacccggcggcggguccggccgugucggcgg
cccggcggaucuuucccgccccccguggggucggcgggggaccguccccc
gaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccg
cgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggc
ccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccg
agggagcgagacccgucgccgcgcucuccccccucggcgucuccucgugg
gggggccgggccaccccucccacggcgcgaccgcucucccaccccucguc
ggggggcggggcggacuguccccagugcgccccgggcgggucgcgccguc
gggcccgggggagguucucucggggccacgcgcgcgucccccgaagaggg
ggacggcggagcgagcgcacggggucggcggcgacgucggcuacccaccc
gacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucggg
ggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcu
cgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcac
caccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacg
uguuaggacccgaaagauggugaacuaugccugggcagggcgaagccaga
ggaaacucugguggagguccguagcgguccugacgugcaaaucggucguc
cgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguu
cccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgca
cccccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggg
gccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccg
gcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuu
ugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcg
cccgaugccgacgcucaucagaccccagaaaagguguugguugauauaga
cagcaggacgguggccauggaagucggaauccgcuaaggaguguguaaca
acucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcguc
gggcccauacccggccgucgccggcagucgagaguggacgggagcggcgg
gggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccg
cgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggc
ccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauuc
aaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagca
guugaacaugggucagucgguccugagagaugggcgagcgccguuccgaa
gggacgggcgauggccuccguugcccucggccgaucgaaagggagucggg
uucagauccccgaauccggaguggcggagaugggcgccgcgaggcgucca
gugcgguaacgcgaccgaucccggagaagccggcgggagccccggggaga
guucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccg
agagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggu
gagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcg
ccgggccguacccauauccgcagcaggucuccaaggugaacagccucugg
cauguuggaacaauguagguaagggaagucggcaagccggauccguaacu
ucgggauaaggauuggcucuaagggcugcagccgacuuagaacuggugcg
gaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccg
cggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaa
gugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacuc
ucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaaug
gaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagc
caagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagc
uugacucuagucuggcacggugaagagacaugagagguguagaauaagug
ggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggg
uccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuu
uucacugacccggugaggcgggggggcgagccccgaggggcucucgcuuc
uggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccgggg
acagugccagguggggaguuugacuggggcgguacaccugucaaacggua
acgcagguguccuaaggcgagcucagggaggacagaaaccucccguggag
cagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagacc
gugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcagga
ggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcgu
ucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauu
gugaagcagaauucaccaagcguuggauuguucacccacuaauagggaac
gugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugau
gauguguuguugccaugguaauccugcucaguacgagaggaaccgcaggu
ucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcua
ccaucugugggauuaugacugaacgccucuaagucagaaucccgcccagg
cggaacgauacggcagcgccgcggagccucgguuggccucggauagccgg
ucccccgccgggaccgggguccggugcggagugcccuucguccugggaaa
cggggcgcggccggagaggcggccgcccccucgcccgucacgcaccggcc
guucguggggaaccuggcgcuaaaccauucguagacgaccugcuucuggg
ucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaa
gucagcccucgacacaaggguuugu
.........................<<<<<<.....<......>......
>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....
>>>>>>..[[[...<<<<...<<<<<<<<<<.....>>>>>>.>>>>...
..>>>>...<<<<<<<<<....<<<<<<<<........<<<<<<<<....
<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>
>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>
>>>>.....(((((..<<<<<<)))))..]]]..................
................<<....>>...............<<<......>>
>....................................<<<<<...<<<..
....<<<<<<<<.<<<.....<<<<<<<<<<<...<<<.<<.<<<<<.<<
...<<<<<.<<..<<<<<<<<<<<..>>>>..>>>>>>>>>>>>>>>>>>
>>>>>....>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<
<<<.<<<<<<<<<..<<<....<.....<<<<.<<.<...<...<<<<<.
>>>>>...>.....>>>.>>>>..........>.>>>....>>>>>>>>>
....................<<<<<..<<<<<<................>
>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<........<<<<....
.>>>>..<<<<<<.<<<<....>>>>.>>>>>>..>>.>>>>>>>>>>>.
>>>...>.>>>...........>>.>...........<<.<........>
>>...........>>>>>......>>>.>>>>>....>>>....>>>>>.
...<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...
<<<<........>>>>.....>>>...<<....>>...<<<<<<<.....
.>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>
>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>
>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<
<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>.
...>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..
<<<<<<....<.<<<....>>>(><<.<<<<<<<................
..............<<<<<<<<....<<<....<<<..<.<<<..<.<..
............>.>.>>>.>..>>>..>.>>....>>>>>>...<<<<<
<<<<........>>>>>>>>>...>>...>>>>>>>..>>).<<<<.<<<
<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(
((.......<<<<<......<..........<<<.<<<<<<<<<<.....
..<<<...<<<...................>>>.........<<......
>>.....>>>...>>>>>>>>>>>>>..........))).>....>>>>>
..>>>...>>>>>>><<<<<<.<<<..........]]..)))........
..............................................>>>>
>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>
>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<
<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<...
..>>.>>>>>>....((<<<<<<...<<....<<<....>>>........
..<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<
........>>>>>))<<<<....<<<<....<<<<<<......>>>>>>.
..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<
<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.
....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.
..>>>>>>>>>>>>.........>>>>>>>..>..........>..>>>.
>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>
>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<
..>>.....>>>>><<.<<<<<<<<<<..>>>>..>>>>>>.>>......
......<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.
....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....
.<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<.........>>>
>.........<...........<<<<<.......>>>>>.....>.....
>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<
<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[
[..<<<<<.<<<<<<<<<.<<<<<<<<<<.....<..............<
.........<<<<<<<<.<<<<...<.<........>>..>>>.>..>>>
..>>>>>........................>......>......>>>>>
>>>>>...<<<<<.....<<<<...<.<<<<<<....>>>>>>>......
.........<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>.
...>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<.........
..>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<
<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<
<<....>>>.>>)))]......((((((..(((..>>>>>>.))))))))
)..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<..
.....>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<.
<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..
>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]
.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.
><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>
...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>..
.>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<
..<<.<<.......>.>>>.>>>>>........>>....<<..<<<<...
.<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>.........
.......>>>..>>>>>>>>><<<<<....................<<.<
<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>
>....>>>>.>>>.>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7a01 The Halastavi arva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism.
Resolution3.6 Å
Binding residue
(original residue number in PDB)
A15 G16 R17 Y38 R48 R51 T54 A55 K59 K60 R65 K67 K73 V74 Y75 N76 H79 K109 R111 R112 K133 R135
Binding residue
(residue number reindexed from 1)
A14 G15 R16 Y37 R47 R50 T53 A54 K58 K59 R64 K66 K72 V73 Y74 N75 H78 K108 R110 R111 K132 R134
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006364 rRNA processing
GO:0006412 translation
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7a01, PDBe:7a01, PDBj:7a01
PDBsum7a01
PubMed33296660
UniProtG1TXF6|RL27_RABIT Large ribosomal subunit protein eL27 (Gene Name=RPL27)

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