Structure of PDB 8uvs Chain 21 Binding Site BS01 |
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>8uvs Chain 2A (length=2800)
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agaugguaagggcccacgguggaugccucggcacccgagccgaugaagga cguggcuaccugcgauaagccagggggagccgguagcgggcguggauccc uggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgc ugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagag gaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccu aaaccguccggcuuguccgggcggggucguggggcccucggacaccgaau ccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagc cccguaggcgaaagguggggggauaggugaggguacccgaguaccccgug guucguggagccaugggggaaucugggcggaccaccgccuaaggcuaagu acuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaaga accccgggaggggagugaaauagagccugaaaccgugggcuuacaagcag ucacggccccggggguuguggcgugccuauugaagcaugagccggcgacu cacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccg aguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaac cgggcgagcuagcccuggccagggugaagcuggggugagacccaguggag gcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggag ugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuu agggucagccucaggcgcugacuggggccuguagagcacugauagggcua gggggcccaccagccuaccaaacccugucaaacuccgaagggucccaggu ggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcggg aacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaa ggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagccc agcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccg augccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcg aaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaa gcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccu aaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggc ccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagc cauggacgagcccggccagaagcgcagggugggagguaggcaaauccgcc ucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccga agccagggagccaagaaaagccucuaagcacaaccugcgggaacccguac cgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggag aacccucgccaaggaacucugcaaguuggccccguaacuucgggagaagg ggugcucccuggggugaugagccccggggagccgcagugaacaggcucug gcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggaggua uagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaag ccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaa gguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaa cgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgu gaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuac ugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagc cugugaacccccgccuccgggugggggggaggcgccggugaaauaccacc cuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgg gcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaa gguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagg gggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccua gugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguu accccggggauaacaggcugaucucccccgagcguccacagcggcgggga gguuuggcaccucgaugucggcucgucgcauccuggggcugaagaagguc ccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucag aacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuug aggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguu ucccagcugucccuccaggggcauaagcuggguagccaugugcggaaggg auaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccuc ccggcagccgguaaggacccgggaagaccacccgguggaugggccggggg uguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu |
<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<< <<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>> >>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<< .>>>>>>.>>...<<<<<<.....<......>......>>>>>.>..... ....<<....>>...<<<<<.....<<.....>>....>>>>>...<<<. ...<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...< <<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....)) >>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<< <<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>..... .>>.>>>>>>.>>...............<<....>>....>>........ .<<<<....>>>>..................>>>>>>>>>>>.......< <<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<.... <<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>. .<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...< <<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.... .>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<< <.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<.. ..>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<... <<<............>.>>...>>>>>>>>..>>.>...>>>>>>>>>.. ...>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<. .....>>>...<<<<.<<<...<<<(((.....<<<<<<........... <<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>> >>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<. ..<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..... ...>>>>>><......<<.....<<<<<<.......>>>>>><<<<.... <<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<. ..<<<...<<<....>>>...>>>...>>...<<<<<........>>>>> ))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<< ..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>> >>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>.. .>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..> >.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<.. ..<<<<<<<<.<<.........<.....<<<<<.....<..>......>> >>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<< <<<..<<<.........>>>..<<<<<<<.....<<<....>>>...... .>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....> >>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>.... ....<...........<<<<<<.....>>>>>>.....>....>>>>>.. >>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<. .......>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<< <<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<< .......<<<<<<<<....>>>>>>>>....>>............>>>>> ..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>.. >>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<... <<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>> >>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))). ......<<<<<<<.<<..))))..>>>>>>>>>.............>>>> ..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>> >...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>> >>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....< <<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<.. .<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<. ..<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<< ....<<<<<...........>>>>>....>>>.>>>>.......>>>>>> >.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<< <....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> |
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PDB | 8uvs Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus. |
Resolution | 2.75 Å |
Binding residue (original residue number in PDB) | S2 K3 K10 R11 V14 A15 N16 Q19 R20 R21 A24 K25 G28 G29 V30 G31 K32 K33 T34 T35 I37 K39 R40 R41 Q42 Y43 P44 N45 Q47 R50 R52 G55 R61 A64 H66 K69 R76 G79 K81 K92 |
Binding residue (residue number reindexed from 1) | S1 K2 K9 R10 V13 A14 N15 Q18 R19 R20 A23 K24 G27 G28 V29 G30 K31 K32 T33 T34 I36 K38 R39 R40 Q41 Y42 P43 N44 Q46 R49 R51 G54 R60 A63 H65 K68 R75 G78 K80 K91 |
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