Structure of PDB 8i0v Chain 2 Binding Site BS01

Receptor Information
>8i0v Chain 2 (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVP
VPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTM
KSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFET
RLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLK
IPGLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTIDRTPWGELE
Ligand information
>8i0v Chain H (length=151) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguuuaucag
uuuaauaucugauggauuuuuggagcagggagauggaauaggagcuugcu
ccguccacuccacgcaucgaccugguauugcaguaccuccaggaacggug
c
..............................................<<<<
........>>>>................<<<<.<<<<...<<<<....>>
>>.>>>>>>>>..<<<<<<.<<<<<.............>>>>>..>>>>>
>
Receptor-Ligand Complex Structure
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PDB8i0v Molecular basis for the activation of human spliceosome
Resolution3.0 Å
Binding residue
(original residue number in PDB)		K452 R456 M477 H478 W504 C505
Binding residue
(residue number reindexed from 1)		K3 R7 M28 H29 W55 C56
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0016607 nuclear speck
GO:0071005 U2-type precatalytic spliceosome
GO:0071011 precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i0v, PDBe:8i0v, PDBj:8i0v
PDBsum8i0v
PubMed39068178
UniProtQ13435|SF3B2_HUMAN Splicing factor 3B subunit 2 (Gene Name=SF3B2)

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