Structure of PDB 8c94 Chain 2 Binding Site BS01

Receptor Information
>8c94 Chain 2 (length=39) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVLKRNRSHGFRARMATKNGRQVLARRRAKGRARLTVSK
Ligand information
>8c94 Chain A (length=1668) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgau
gaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguu
auaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuau
cauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacau
cuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcg
agcgaacggggagcagcccagagccugaaucaguguguguguuaguggaa
gcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaug
cacaugcugugagcucgaugaguagggcgggacacgugguauccugucug
aauauggggggaccauccuccaaggcuaaauacuccugacugaccgauag
ugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagug
aaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggc
gugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguag
caagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggc
guuaaguugcaggguauagacccgaaacccggugaucaccgggagauagc
ugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccgg
ggguagagcacuguuucggcccgaugcaaacugcgaauaccggagaaugu
uaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaa
caacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacg
augugggagccugcgcggauaacggggcuaaaccaugcaccgaagcugcg
gcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcg
aaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugaca
uaaguaacaaagcgggugaaaagcccgcucgccggaagaccaagugguca
gguagagaauaccaaggcgcugagagaacucgggugaaggaacagacuca
gugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaa
aguccuccuaaagaguaacggaggagcacgaagguuggcuaauccugguc
ggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgu
gacggcgcgagcaggugcgaaagcaggucauagugauccggugguucuga
auggaagggccaucgcucaacggucccuaucugccgugggcgcuggagaa
cugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacug
guguucggguugucaugccaauggcacugcccgguagcuaaaugcggaag
agauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguuc
ucccugacccuuuaaggguccugaaggaacguugaagacgacgacguuga
uaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaug
aaccgugaggcuuaaccu
<<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<<...
...<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>...
...>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<
<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......
>......>>>>>.>.........<<....>>..<<<<<<.....<<....
.>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...
<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>
>>>>>>>>>...>>>>........<<..<<<<.........>>>>..>>.
.....<<<<<..{.[[>>>>>..>>>......>>.>>>>>>>.>>.....
..........<<....>>....>>.........<<<<.....>>>>....
.........>....>>>>>>>>>>>.......<<<<..<<<<<......>
>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<
<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>
.....>>>>>>>>>>>>>..<<.<..<<<<<<<....>>>>>>...>..>
.>>..<<<<<<....<<<<<....>>>>>..<<<<<<<...<<<<<<<.<
<....<<<...<<<.<<<<.>>>>.>>>..>>.>.....>>>>>>.>>>.
..>>>>>>>.....<<<<<<<<<<......>>>>>>>>>>....<<<...
...>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<
..<<<<<..>>>>>.>>......))).....>>>>>>.>>>...>>>>>>
><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<....
..<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><
......<<..<<<<<<.......>>>>>><<<<....<<<<<..>>>>>.
..<<.....>>....>>>>.<<<<....<<.............>>.>>>>
>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<..
..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..
.....>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<
....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..
]]}...>>>>>>>>>..........>>..>>>>>>>>>>>....<<<<<<
<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<
<<...<<<<<<<<<<<....>>>>>>..>>>>>...>>>>.>>>>>...<
<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>
>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....
<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...
..>>..>..>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB8c94 Cryo-EM captures early ribosome assembly in action.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		L10 K11 R12 N13 R14 H16 F18 R19 R21 N26 R28 R34 R35 K37 G38 R39 T43 K46
Binding residue
(residue number reindexed from 1)		L3 K4 R5 N6 R7 H9 F11 R12 R14 N19 R21 R27 R28 K30 G31 R32 T36 K39
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c94, PDBe:8c94, PDBj:8c94
PDBsum8c94
PubMed36797249
UniProtP0A7P5|RL34_ECOLI Large ribosomal subunit protein bL34 (Gene Name=rpmH)

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